Gene interactions and pathways from curated databases and text-mining

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PTH — SCT

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Takiyyuddin et al., J Clin Endocrinol Metab 1991 (Hypoglycemia) : Secretin suppressed plasma PTH and calcitonin, but did not alter plasma CgA levels
Benson et al., Acta Med Scand 1985 (Hyperparathyroidism...) : Effects of secretin on parathyroid hormone and calcium in normal subjects, patients with hyperparathyroidism and patients with gastrinoma ... In vitro studies have demonstrated that secretin can stimulate the release of parathyroid hormone (PTH) , but reports concerning its effects on PTH and calcium in vivo are contradictory
Sethi et al., J Clin Endocrinol Metab 1983 (Anemia, Pernicious) : Effect of meal on serum parathyroid hormone and calcitonin : possible role of secretin
Sethi et al., J Clin Endocrinol Metab 1981 : Effect of secretin on parathyroid hormone and calcitonin secretion ... The effect of secretin on secretion of parathyroid hormone (PTH) and calcitonin ( CT ) was evaluated by both in vitro and in vivo techniques ... In in vitro studies with bovine parathyroid tissue, Secretin-Boots caused significant dose related increases in PTH secretion ... In in vitro studies with rat thyroparathyroid tissue, Secretin-Boots caused significant increases in both PTH and CT secretion ... These data suggest that secretin can stimulate hormonal secretion by parathyroid and thyroid C cells and that secretin may play a modulating role in the secretion of both PTH and CT