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ITGA4 — PTK2
Pathways - manually collected, often from reviews:
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KEGG Regulation of actin cytoskeleton:
ITGA1/ITGA10/ITGA11/ITGA2/ITGA2B/ITGA3/ITGA4/ITGA5/ITGA6/ITGA7/ITGA8/ITGA9/ITGAD/ITGAE/ITGAL/ITGAM/ITGAV/ITGAX/ITGB1/ITGB2/ITGB3/ITGB4/ITGB5/ITGB6/ITGB7/ITGB8
→
Complex of BCAR1-CRK-CRKL-PTK2
(protein-protein, activation)
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NCI Pathway Database CXCR4-mediated signaling events:
alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1)
→
FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN)
(cell adhesion, collaborate)
Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
Evidence: mutant phenotype, assay
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NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
FAK (PTK2)
(modification, activates)
Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
Evidence: mutant phenotype
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NCI Pathway Database a4b7 Integrin signaling:
alpha4/beta7 Integrin complex (ITGA4-ITGB7)
→
FAK (PTK2)
(modification, activates)
Manie et al., Blood 1996
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nojima et al., J Exp Med 1992
:
Here, we report that the engagement of
VLA-4 on T cells with specific antibodies or its ligand
activates protein-tyrosine kinase ( PTK ) activity as detected by antiphosphotyrosine immunoblotting
Oostendorp et al., Leukemia & lymphoma 1997
:
It has been demonstrated that ligation of
VLA-4 induces phosphorylation of the protein tyrosine kinase ( PTK )
pp125FAK as well as other proteins which may be involved in the regulation of ligand affinity