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PPP2R1A — RAF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database PDGFR-beta signaling pathway:
PP2A complex (PPP2R1A-PPP2R2B-PPP2CA)
→
RAF1/14-3-3 (dimer) complex (RAF1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, activates)
Mason et al., EMBO J 1999, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Dhillon et al., Cell Signal 2009, Ritt et al., Mol Cell Biol 2010, Michaud et al., Mol Cell Biol 1995, Muslin et al., Cell 1996
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Jaumot et al., Oncogene 2001
:
Inhibition of PP1 and
PP2A therefore
causes plasma membrane accumulation of
Raf-1/14-3-3 complexes which can not be activated
Chetoui et al., Mol Immunol 2006
:
Activation of
PP2A was not necessary for the binding of Coll I to Jurkat T cells, but is
required for the activation of
Raf-1