Lenz et al., Br J Pharmacol 2000
:
cRaf-1 , the first kinase in the Erk cascade, was activated by 2MeSATP, ADP and UTP but, surprisingly, cRaf-1 was not stimulated by ATP
Graham et al., Biochem J 1996
:
Pretreatment of cells with forskolin abolished the initial activation of MAP kinase kinase or c-Raf-1 by UTP , but only affected MAP kinase activity during prolonged stimulation