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IRF1 — NOS2

Text-mined interactions from Literome

Pavlovic et al., Eur Cytokine Netw 1999 : In conclusion, IRF-1 contributes to cytokine induced islet iNOS expression and cell death
Kelley et al., J Clin Invest 2000 (Cystic Fibrosis) : Therefore, we examined the expression levels of regulatory factors necessary for NOS2 expression in CF epithelium and showed that IFN regulatory factor-1 (IRF-1) is necessary for full NOS2 expression
Samardzic et al., Cytokine 2001 : These results indicate that STAT1 activation and subsequent IRF-1 transcription are required for induction of iNOS , but not IL-6 in murine fibroblasts
Blair et al., J Biol Chem 2002 : Role of interferon regulatory factor-1 in double stranded RNA induced iNOS expression by mouse islets ... In this study, we show that IRF-1 is not required for dsRNA + IFN-gamma stimulated iNOS expression and nitric oxide production by mouse islets ... These results indicate that IRF-1 is required for dsRNA + IFN-gamma induced iNOS expression and nitric oxide production by mouse peritoneal macrophages but not by mouse islets
Teng et al., Am J Physiol Cell Physiol 2002 : We conclude that in RASMC, NF-kappa B and C/EBP mediate the IL-1 beta induced iNOS expression, whereas IRF-1 and STAT1 mediate the IFN-gamma enhanced iNOS induction
Miljkovic et al., Glia 2002 : This IRF-1 dependent inhibition of iNOS activation might be partly responsible for the protective effect of MPA in EAE, prompting investigation of its potential use in multiple sclerosis
Xiong et al., J Biol Chem 2003 : In addition, interleukin-4 inhibits IFN-gamma induced iNOS gene expression by attenuating the physical interaction of ICSBP with IRF-1
Yamada et al., Microbiol Immunol 2002 (Tuberculosis, Pulmonary) : IRF-1 is indirectly responsible for iNOS mRNA expression and plays an important role in the pathogenesis of murine tuberculosis
Fritsche et al., J Immunol 2003 : Cells carrying functional Nramp1 express increased amounts of NO, which may be related to STAT-1 mediated stimulation of IRF-1 expression with subsequent prolonged activation of iNOS transcription
Baker et al., Surgery 2003 : Transcription factor IRF-1 mediates cytokine induced islet dysfunction, apoptosis, and iNOS gene expression but down-regulates IP-10 gene expression
Rapizzi et al., Mol Pharmacol 2004 (Inflammation) : Consistent with a PAR dependent transcriptional activation, increases of iNOS and COX-2 transcripts were not caused by activation of transcription factors such as nuclear factor-kappaB, activator protein-1, signal transducer and activator of transcription-1 or interferon regulatory factor-1 , nor by mRNA stabilization
De Stefano et al., J Mol Med (Berl) 2006 (Celiac Disease) : The role of NF-kappaB, IRF-1 , and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages ... The role of NF-kappaB, IRF-1 , and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages
Maratheftis et al., Leuk Res 2006 (Myelodysplastic Syndromes) : IRF-1 induced iNOS mRNA expression was exclusively detected in BMMC having full-length transcript
Koide et al., J Endotoxin Res 2007 : SB203580, an inhibitor of p38 mitogen activated protein kinase ( MAPK ), prevented the nuclear translocation of IRF-1 in LPS and IFN-gamma stimulated END-D cells, and inhibited the iNOS expression and NO production in those cells
Do et al., J Nutr Biochem 2010 (Brain Neoplasms...) : Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT, AP-1 and IRF-1 , and depends on up-regulation of scavenger receptor B1 expression in TNF-alpha- and IFN-gamma stimulated C6 glioma cells
Kamijo et al., Science 1994 (Tuberculosis) : Thus, IRF-1 is essential for iNOS activation in murine macrophages ... Thus, IRF-1 is essential for iNOS activation in murine macrophages
Martin et al., J Exp Med 1994 : Role of interferon regulatory factor 1 in induction of nitric oxide synthase
Vilcek et al., Int Arch Allergy Immunol 1994 (Bacterial Infections) : Other studies have shown that the transcription factor IRF-1 is essential for the IFN-gamma mediated activation of the gene for the inducible nitric oxide synthase
Hecker et al., Br J Pharmacol 1996 : Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages : role of nuclear factor kappa B and interferon regulatory factor 1
Bachmaier et al., Circulation 1997 (Inflammation...) : The transcription factor IRF-1 controls iNOS expression and NO synthesis in disease
Shiraishi et al., J Immunol 1997 (Synovitis) : Nitric oxide ( NO ) is involved with the pathogenesis of arthritis, and IRF-1 regulates expression of inducible NO synthase (iNOS) in mononuclear phagocytes ... This was in contrast to the expected decrease in NO production by peritoneal macrophages from IRF-1-/- mice, suggesting that IRF-1 is not required for iNOS expression in chondrocytes
Kinugawa et al., Circ Res 1997 : These data suggest that ( 1 ) iNOS induction simultaneously requires both NF-kappa B activation and IRF-1 induction, and ( 2 ) the heterodimer between C/EBP and CREB has synergistic effects on the iNOS induction via the CAAT box