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IL1A — NOS1
Text-mined interactions from Literome
Hattori et al., Hypertension 1999
:
Thus troglitazone appears to enhance
IL-1 induced
NOS mRNA levels by prolonging its half-life rather than activating its transcription, which is nuclear factor -kappaB dependent
Däubener et al., Adv Exp Med Biol 1999
:
We were able to show that the
IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced IDO activity in uroepithelial cells is
due to stimulation of inducible
nitric oxide synthase
Ochoa et al., Ann Surg 2001
(Wounds and Injuries) :
In contrast,
nitric oxide synthase expression is
induced by
IL-1 , tumor necrosis factor, and gamma interferon, a T-helper 1 cytokine profile
Kilbourn et al., J Natl Cancer Inst 1992
(Hypotension) :
Inhibition of
interleukin-1-alpha induced
nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha induced hypotension by N omega-amino-L-arginine
Eizirik et al., FEBS Lett 1992
:
Furthermore,
IL-1 beta markedly
increased the mRNA levels of the inducible macrophage form of
nitric oxide synthase in HIT cells
Ortega-Gutiérrez et al., FASEB J 2005
(Multiple Sclerosis) :
Additionally, in microglial cells, UCM707 decreases the production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha,
interleukin (IL)-1beta , and IL-6 ;
reduces nitric oxide levels and inducible
nitric oxide synthase expression ; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide
Li et al., Arterioscler Thromb Vasc Biol 2007
(Inflammation) :
FXR ligands induced smooth muscle cell death and downregulated
interleukin (IL)-1beta induced inducible
nitric oxide synthase and cyclooxygenase-2 expression
Gądek-Michalska et al., Pharmacol Rep 2012
:
In the hypothalamus the
IL-1ß induced initial significant increase of
nNOS regularly decreased in a modest rate and remained at significant higher level compared to control values
Winston et al., Am J Physiol Gastrointest Liver Physiol 2013
(Colitis, Ulcerative...) :
NF-?B inhibitor MG-132 did not prevent the
IL-1ß induced decline in either ChAT or
nNOS expression
Marumo et al., Jpn J Pharmacol 1993
:
Dexamethasone inhibits
nitric oxide synthase mRNA
induction by
interleukin-1 alpha and tumor necrosis factor-alpha in vascular smooth muscle cells
Hewett et al., Neurosci Lett 1993
:
We demonstrate by immunoprecipitation and nitrite formation that
interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma)
induce the expression of
nitric oxide synthase in primary cultures of murine cortical astrocytes
Tetsuka et al., Am J Physiol 1995
:
The inflammatory cytokine
interleukin-1 (IL-1) induces the inducible form of
nitric oxide synthase ( iNOS ) with an increase in nitric oxide in rat mesangial cells
Ma et al., J Biol Chem 1996
:
IL-1 increases islet expression of
nitric oxide ( NO ) synthase , and the resultant overproduction of NO participates in inhibition of insulin secretion because NO synthase inhibitors, e.g. NG-monomethyl-arginine ( NMMA ), prevent this inhibition
Kitade et al., Hepatology 1996
:
Furthermore,
IL-1 beta markedly
increased NOS activity, and this increase in activity was accompanied by the expression of inducible NOS (iNOS) messenger RNA ( mRNA )
Romero et al., Am J Physiol 1996
:
Roles of
IL-1 and TNF-alpha in endotoxin induced activation of
nitric oxide synthase in cultured rat brain cells ... To determine whether LPS induction of
NOS in brain cells is
mediated by
IL-1 or TNF-alpha, acting alone or in concert, the effects of IL-1-receptor antagonist (IL-1Ra) and of TNF-soluble receptor ( TNFsRp55 ), presented individually and in combination, on LPS induced NOS activity were tested
Hauber et al., Cell Immunol 1997
:
We show that gene expression of
IL-1 alpha , IL-1 beta, IL-6, granulocyte-colony stimulating factor, and IL-10 was
induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible
nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs
Newton et al., Eur J Biochem 1998
(Inflammation) :
However, in these cells,
IL-1beta induction of inducible
nitric oxide synthase , granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone