Wajapeyee et al., Cell 2008
(MAP Kinase Signaling System...) :
Expression of BRAFV600E in primary cells leads to synthesis and secretion of IGFBP7 , which acts through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling and induce senescence and apoptosis
Liu et al., Cell Biochem Biophys 2012
:
IGFBP7 could also inhibit the phosphorylation of ERK and the expression of PCNA, MMP2 and MMP9 in HTR-8 and JEG-3 cells