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EPHB2 — TGFB1

Text-mined interactions from Literome

Hamaguchi et al., Hypertension 1999 (Hypertension) : Thus, we show that ERK , through AP-1 activation, is involved in Ang II-induced TGF-beta(1) mRNA expression in VSMCs and suggest that ERK may participate in vascular remodeling of hypertension
Cospedal et al., Biochem J 1999 : TGF-beta(1) had no inhibitory effect on ERK activation induced by PDGF-BB or bFGF
Yonekura et al., Endocr J 1999 : TGF-beta1 induced a rapid activation of extracellular signal regulated kinase ( ERK ) with a peak at 5 min, which decreased to basal levels within 240 min after TGF-beta1 stimulation ... ERK activation by TGF-beta1 was also confirmed by in vivo phosphorylation assays of Elk1
Finlay et al., J Biol Chem 2000 : Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of TGF-beta1 induced ERK/AP-1 activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody
Schiött et al., Immunol Lett 2000 : In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK , a MAP-kinase downstream of the Ras pathway
Isono et al., J Am Soc Nephrol 2000 : The conclusion is that activation of ERK in mesangial cells is responsible for high-glucose induced stimulation of TGF-beta1 and contributes to the increased extracellular matrix expression
Hashimoto et al., Am J Respir Crit Care Med 2001 : The results showed that : ( 1 ) TGF-beta1 caused the phenotypic modulation of HLF to myofibroblasts in a dose- and a time dependent manner ; ( 2 ) TGF-beta1 induced increases in c-Jun-NH2- terminal kinase (JNK), p38 MAPK, and extracellular signal regulated kinase ( Erk ) phosphorylation and activity ; ( 3 ) the inhibitors CEP-1347, SB 203580, and PD 98059 attenuated TGF-beta1 induced JNK, p38 MAPK, and Erk activity, respectively ; and ( 4 ) CEP-1347, but not SB 203580 or PD 98059, attenuated the TGF-beta1 induced phenotypic modulation of HLF to myofibroblasts in a dose dependent manner
Ellenrieder et al., Cancer Res 2001 (MAP Kinase Signaling System...) : In the responsive cell lines, TGF-beta1 induced a moderate but sustained activation of ERK2
Kalina et al., Exp Hematol 2001 (Leukemia, Erythroblastic, Acute...) : As demonstrated by Western blotting, TGF-beta1 reduced the TPO stimulated ERK1/ERK2 and STAT5 phosphorylation in Mo-7e and HEL cells
Kutz et al., J Cell Sci 2001 : MEK appeared to be a major mediator of TGF-beta1 dependent PAI-1 expression and T2 cell motility since PD98059 effectively attenuated both TGF-beta1 induced ERK1/2 activation and PAI-1 transcription as well as basal and growth factor stimulated planar migration
Kobayashi et al., Hypertens Res 2002 (Body Weight...) : Thus, we conclude that ERK1/2 and p70S6 kinase activities may play a key role in coronary microvascular remodeling of Dahl salt-sensitive hypertensive rats, and that beneficial effects of betaxolol on cardiovascular remodeling may be at least partially mediated by decreased PDGF A-chain and TGF-beta1 expression in the left ventricle
Sowa et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3 induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells
Lhuillier et al., J Neurophysiol 2002 : The acute effects of TGFbeta1 on K ( Ca ) channels are mediated by posttranslational events and require activation of the MAP kinase Erk ... Application of the MEK1 inhibitor PD98059 blocked TGFbeta1 effects on Erk but had no effect on Akt/PKB phosphorylation
Grände et al., J Cell Sci 2002 (Cell Transformation, Neoplastic...) : TGF-beta1 only partially inhibited EGF induced Erk phosphorylation
Lu et al., J Cell Sci 2002 : alpha8beta1 binding to LAP-TGFbeta1 increased cell proliferation and phosphorylation of FAK and ERK , but did not activate of TGFbeta1
Cohen et al., J Lab Clin Med 2003 : Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal regulated kinase ( ERK ), and stimulates ERK dependent transforming growth factor-beta 1 production in macrophage RAW cells
Utsugi et al., Am J Respir Cell Mol Biol 2003 : TGF-beta1 activated c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase, but not ERK in HFL-1 cells
Frank et al., J Biol Chem 2003 : Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2 dependent mechanism
Luettich et al., Molecular cancer 2003 (MAP Kinase Signaling System) : TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin
Osman et al., J Biol Chem 2004 : Expression of functional Schistosoma mansoni Smad4 : role in Erk mediated transforming growth factor beta ( TGF-beta ) down-regulation
Tanaka et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Here, we show that 1 ) nontoxic concentrations of TGF-beta1 activated Src kinase ; 2 ) TGF-beta1 rapidly phosphorylates ERK1/2 and Akt, but not p38 ; 3 ) pharmacological Src inhibitor PP2 or antisense ( AS ) c-Src oligodeoxynucleotide ( ODN ) treatment reduced TGF-beta1 induced phosphorylation of ERK1/2 and Akt by 85-90 % compared with controls ; 4 ) pharmacological inhibition of MAPK by PD98059 abrogated TGF-beta1 mediated Akt stimulation, whereas TGF-beta1 induced ERK1/2 stimulation was not inhibited by PI3K inhibitor LY294002 or AS-PI3K ODN transfection ; 5 ) up-regulation of uPA mRNA in response to TGF-beta1 was almost totally blocked by PP2 and PD98059 and partially ( approximately 55 % ) by LY294002 ; 6 ) TGF-beta1 induced uPA mRNA up-regulation was inhibited by treatment with AS ODNs to c-Src or PI3K by 90 or 60 %, respectively, compared with control ODN treatment ; and 7 ) blockade of the release of the transcription factor NF-kappaB by pyrrolidinedithiocarbamate reduced the TGF-beta1 induced activation of the uPA gene by approximately 65 %
Kim et al., J Biol Chem 2004 (Carcinoma, Hepatocellular...) : In MLK3 overexpressing cells, ERK , JNKs, and p38 MAP kinases were further activated in response to TGF-beta1 compared with the control cells
Kim et al., Int J Biochem Cell Biol 2004 (MAP Kinase Signaling System) : These results suggest that the ERK pathway may be involved in the melanogenic signaling cascade, and that delayed ERK activation by TGF-beta1 contributes to reduced melanin synthesis via MITF down-regulation
Munshi et al., J Biol Chem 2004 (Carcinoma, Squamous Cell...) : TGF-beta1 induced concomitant activation of ERK1/2 and p38 MAPK, and kinase inhibition studies revealed a negative regulatory role for ERK1/2 in modulating acquisition of MMP-2 activity
Luo et al., Am J Physiol Endocrinol Metab 2004 (MAP Kinase Signaling System) : TGF-beta1 and GnRHa increased ERK1/2 nuclear accumulation and inversely regulated the expression of c-fos and c-jun and that of fibronectin in a cell-specific manner
Xue et al., Zhonghua Gan Zang Bing Za Zhi 2004 : SA-B inhibits ERK signaling induced by TGF-b1 in HSC
Marek et al., J Cell Physiol 2004 : Like NFLC, induction of urokinase plasminogen activator (uPAR), transin/matrix metalloproteinase 3 (MMP3), Fra-1 and transforming growth factor beta 1 ( TGF beta 1 ) required collaborative ERK and JNK signaling while the increased expression of cortexin, rat collapsin response mediator protein 4 ( rCRMP4 ), rat growth and transformation dependent protein ( RGT ), and synapsin II required neither mitogen activated protein kinase ( MAPK ) pathway
Suzuki et al., Clin Exp Nephrol 2004 : Exogenous TGF-beta1 under both normal and high glucose, enhanced the phosphorylation of both p38 MAP kinase and ERK1/ERK2 , but not that of JNK
Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Antioxidants effectively inhibited TGF-beta1 induced cellular ROS, phosphorylation of Smad 2, p38 MAPK, and ERK , and EMT
Nakagawa et al., J Am Soc Nephrol 2005 : Whereas blocking of ERK1/2 or p38 failed to inhibit TGF-beta1 induced Smad2 activation, inhibition of Smad2 by Smad7 overexpression inhibited the phosphorylation of ERK1/2 but not p38 in response to TGF-beta1 ... In conclusion, TSP-1 expression is regulated by both ERK1/2 and p38 MAPK in rat proximal tubular cells and mouse fibroblasts in response to TGF-beta1
Kim et al., Invest Ophthalmol Vis Sci 2005 : To evaluate the effects of TGF-beta1 and doxycycline on production of gelatinase MMP-9 and activation of Smad, c-Jun N-terminal kinase (JNK), extracellular regulated kinase (ERK) , and p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells ... TGF-beta1 also induced activation of Smad2, JNK1/2, ERK1/2 , and p38 within 5 to 15 minutes, with peak activation at 15 to 60 minutes
Chen et al., Immunology 2005 (HIV Infections) : TGF-beta1 up-regulated CXCR4 and enhanced SDF-1alpha stimulated ERK1,2 phosphorylation in these cells
Inagaki et al., J Biol Chem 2005 : Here, we show that 1 ) KTI suppressed TGF-beta1 induced phosphorylation of Src, ERK1/2 , and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells
Hu et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2005 : ( 3 ) The inhibitors SB203580 and PD98059 suppressed TGF-beta1 induced p38 kinase and Erk phosphorylation respectively
Huo et al., Cell Biol Toxicol 2007 (MAP Kinase Signaling System) : Here, we explore the role of TGF-beta/Smads signaling compounds in TGF-beta1 mediated activation of extracellular signal regulated kinase ( ERK ) MAPK in human papillomavirus ( HPV ) -18 immortalized human bronchial epithelial cell line BEP2D and the role of TGF-beta1 induced phosphorylation of ERK in proliferation and apoptosis of BEP2D ... Our results demonstrate that TGF-beta1 activates ERK in a time dependent manner with a maximum effect at 60 min ; overexpression of Smad7 increased this TGF-beta1 mediated phosphorylation of the ERK ; and siRNA mediated silencing of TbetaRII, Smad3, Smad4, and Smad7 abrogated this effect ... Moreover, we observed that overexpression of Smad7 restored TGF-beta1 mediated ERK phosphorylation in Smad4 knockdown cells but not in TbetaRII knockdown cells ... These data revealed that TbetaRII and Smad7 play the critical roles in TGF-beta1 mediated activation of ERK ; Smad3 and Smad4 can play an indirect role through up-regulating Smad7 expression ; and TGF-beta1 induced phosphorylation of ERK may participate in BEP2D cell proliferation and apoptosis regulation
Poleni et al., Osteoarthritis Cartilage 2007 : TGF-beta1 induced phosphorylation of Smad2/3 and ERK1/2 was reduced by ROSI over GW501516 but not by Wy14643 whereas stimulated PGE2 production was inhibited by Wy14643 over GW501516 but not by ROSI
Luo et al., Zhonghua Yi Xue Za Zhi 2006 : The present study was designed to evaluate the role of MAPK/ERK1/2 phosphorylation in mediating the synthesis of TGF-beta1 in renal tubular epithelial cells that was activated by aldosterone
Dhandapani et al., J Neurosci Res 2007 (Brain Neoplasms...) : Induction of transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation
Huang et al., Kidney Int 2007 : An ERK kinase inhibitor significantly reduced the renin induced ERK1/2 phosphorylation and the subsequent increase in transforming growth factor-beta1 ( TGF-beta1 ) and plasminogen activator inhibitor-1 mRNA expression
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : ERK phosphorylation was increased by IL-13 and IL-13+TGF-beta1
Guo et al., Chin Med J (Engl) 2007 (Rhabdomyosarcoma) : And, exogenous TGF-beta1 stimulation can lead to higher expression of ERK2 and its nuclear translocation, so TGF-beta1 can also activated MAPK ( ERK2 ) pathway, resulting in a sustained activation of ERK2 for at least 2 hours ... The activation of ERK2 by TGF-beta1 may be Smad4 independent
Xie et al., Am J Physiol Lung Cell Mol Physiol 2007 (Asthma...) : The mitogenic activity of TGF-beta1 on ASM cells was inhibited by selective inhibitors of TGF-beta receptor I kinase ( SD-208 ), phosphatidylinositol 3-kinase ( PI3K, LY-294002 ), ERK ( PD-98059 ), JNK ( SP-600125 ), and NF-kappaB ( AS-602868 )
Moon et al., Int J Biochem Cell Biol 2007 : In a previous study, we reported that SPC induces differentiation of human adipose tissue derived mesenchymal stem cells ( hATSCs ) to smooth muscle-like cell types through ERK dependent autocrine secretion of TGF-beta1 and delayed activation of the TGF-beta1-Smad pathway
Lee et al., J Biol Chem 2007 : The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta mediated ERK activation and migration in endothelial cells
Lai et al., Int J Dermatol 2007 : The cellular morphology, mitogenic activities, expression of keratinocyte growth factor (KGF) and transforming growth factor beta-1 ( TGF-beta1 ), and activation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways of dermal fibroblasts were studied after ultrasound treatment
Semlali et al., Am J Respir Cell Mol Biol 2008 (Asthma...) : Inhibition of TGF-beta(1) signaling in asthmatic epithelial cells restored EGFR, ERK1/2 phosphorylation, and cell proliferation induced by EGF
Liu et al., Zhonghua Wai Ke Za Zhi 2007 (Bronchiolitis Obliterans...) : Further study in Smad3-deficient fibroblasts demonstrates that p38 and ERK1/2 could be activated by TGF-beta1 and result in fibroblast differentiation
Dittmer et al., Cancer Lett 2008 (Breast Neoplasms) : TGFbeta1 , a stimulator of PTHrP transcription, abolished the effect of PTHrP and KISS-1 specific siRNAs and increased ERK1/2 phosphorylation, whereas inhibition of ERK1/2 phosphorylation by U0126 reduced colony size
Lee et al., American journal of physiology. Renal physiology 2008 : In this study, we aimed to determine whether the sevoflurane mediated phosphorylation of ERK and Akt, induction of HSP70, and reduction in NF-kappaB activation are due to TGF-beta1 receptor mediated signaling after PS externalization in HK-2 cells
Wei et al., Mol Carcinog 2008 (Breast Neoplasms) : Taken together, these results suggest that the osteoblast derived TGF-beta1 acts through Akt and ERK , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 and beta3 integrins and contributing the migration of breast cancer cell
Samarakoon et al., J Mol Cell Cardiol 2008 : Genetic EGFR deficiency or infection of VSMCs with EGFR ( K721A ) virtually ablated TGF-beta1 stimulated ERK1/2 activation as well as PAI-1 expression but not SMAD2 phosphorylation
Arnott et al., Bone 2008 : Using dominant negative ( DN ) mutants for Erk, Jnk and p38, we demonstrated that the expression of DN-Erk caused a significant inhibition of TGF-beta1 induced CTGF promoter activity
Dorado et al., Nephrol Dial Transplant 2008 : In cultured human mesangial cells, Erk5 was activated by foetal calf serum ( FCS ), high glucose, endothelin-1, platelet activating factor (PAF), epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 )
Ding et al., J Biol Chem 2008 (Disease Models, Animal...) : FRNK overexpression blocks TGF-beta1 induced ERK or p38 MAPK activation in the presence, and surprisingly, in the absence of FAK
Xing et al., Invest Ophthalmol Vis Sci 2009 : TGFbeta1 increased the phosphorylation of ERK and Smad3
Surachetpong et al., PLoS Pathog 2009 (MAP Kinase Signaling System) : Specifically, MEK-ERK signaling was dose-dependently induced in response to TGF-beta1 in immortalized cells in vitro and in the A. stephensi midgut epithelium in vivo
Wang et al., Pharmazie 2009 : Fluorofenidone significantly reduced the phosphorylation of ERK1/2 , P38 and JNK induced by TGF-beta1
Ardura et al., J Am Soc Nephrol 2010 (Disease Models, Animal...) : Inhibition of EGFR activation abolished these EMT related changes, the activation of ERK1/2 , and upregulation of TGF-beta1 and VEGF by PTHrP ( 1-36 )
Ling et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009 : The effect of TGF-beta1 , Staurosporine, PD98059 and matrine on the expression of CTGF, CTGF mRNA, p-Smad2, and p-ERK1/2 were evaluated by Western blot in cultured HLF-02 cells
Simpson et al., Am J Pathol 2010 : Taken together, these results demonstrate that HA can serve as a signal integrator by facilitating TGF-beta1 mediated CD44-EGF-R-ERK interactions and ultimately fibroblast phenotype
Peng et al., Am J Physiol Heart Circ Physiol 2010 : We investigated the effect of Ac-SDKP on TGF-beta1 induced HCF transformation into myofibroblasts, Smad2 and ERK1/2 phosphorylation, Smad7 expression, cell proliferation, and collagen production ... TGF-beta1 also increased Smad2 and ERK1/2 phosphorylation but did not affect Smad7 expression
Fernández-Calotti et al., J Biol Chem 2010 (Leukemia, Lymphocytic, Chronic, B-Cell...) : TGF-beta1 acts through activation of ERK1/2 and the small GTPase RhoA to promote plasma membrane trafficking of the hCNT3 protein
Jung et al., Eur J Pharmacol 2010 (Diabetes Mellitus) : CS inhibited S100b induced TGF-beta1 and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3, extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase ( MAPK ), and oxidative stress
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : Our results show, for the first time, that TSA inhibits TGF-beta1 induced ERK activation and overrides pro-apoptotic signals like Smad3 and p38 in human RPTECs
Jiang et al., Int J Mol Med 2010 (MAP Kinase Signaling System) : Transient transfection of a dominant negative Smad2 construct significantly decreased TGF-beta1 induced phosphorylation of ERK1/2 , JNK and expression of collagen IV, but did not decrease the phosphorylation of p38
Chen et al., Pharmazie 2012 (Fibrosis) : Furthermore, AKF-PD significantly blocked TGF-beta1 induced phosphorylation of ERK
Wei et al., Spine (Phila Pa 1976) 2013 : Gene expression of ADAMTS-4, ADAMTS-5, and TGF-b were not affected by IL-1 or ERK inhibition
Mucsi et al., J Biol Chem 1996 : TGF-beta1 increased ERK1 activity 4.5-fold at 5 min and 3