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BMP6 — SPP1

Text-mined interactions from Literome

Yang et al., J Biol Chem 2000 : Previously, we have reported that Smad1 activates osteopontin gene expression in response to bone morphogenetic protein simulation through an interaction with a homeodomain transcription factor, Hoxc-8
Xu et al., Cell Biol Int 2004 : BMP-6 stimulated the expression of osteopontin , BMP-2, ALPase and osteoprotegerin
Osyczka et al., Endocrinology 2005 : Either treating human MSC cultures with the MAPK/ERK kinase inhibitor PD98059 or transferring them to serum-free medium with insulin or IGF-I permits BMP dependent increases in the expression of the early osteoblast associated genes, alkaline phosphatase and osteopontin ... In contrast, inhibiting the insulin/IGF-I activated PI3-K/AKT pathway decreases BMP induced alkaline phosphatase and osteopontin expression in serum-free cultures of human MSC, but increases BMP activation of Smads ; thus, PI3-K signaling is required for BMP induced expression of early osteoblast genes in human MSC either downstream or independent of the BMP activated Smad signaling pathway
Shen et al., Exp Cell Res 2007 : Antisense targeting of TGF-beta1 augments BMP induced upregulation of osteopontin , type I collagen and Cbfa1 in human Saos-2 cells
Muthukuru et al., J Periodontol 2013 : Results : BMP2 was a potent inducer of osteocalcin/osteopontin ( statistically significant at P < 0.01 ) and osteonectin in PDL cells relative to stimulation with doxycycline