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GATA3 — IL4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ferber et al., Clin Immunol 1999
:
We now show that ectopic expression of
GATA-3 in developing Th1 cells significantly
inhibits IFN-gamma, as well as enhancing
IL-4 and IL-5 production
Heath et al., Eur J Immunol 2000
:
TGF-beta1 down-regulates Th2 development and results in decreased
IL-4 induced STAT6 activation and
GATA-3 expression
Lantelme et al., Immunology 2001
:
During T-cell commitment the presence of
IL-4 in the culture was essential to maintain or
enhance GATA-3 transcription, while IL-12 was not necessary for full repression of GATA-3
Ranganath et al., Mol Cell Biol 2001
:
IL-4 induction by
GATA-3 required each of the functional domains to be present, whereas repression of gamma interferon could occur even when mutants of GATA-3 lacking the second transactivation domain, TA2, were expressed
Grogan et al., Immunity 2001
:
Although T cells transcribed both IFN-gamma and
IL-4 within hours in a Stat4-/Stat6 independent manner, neither T-bet nor
GATA-3 was
induced optimally without Stat signals, and polarized cytokine expression was not sustained
Christodoulopoulos et al., J Allergy Clin Immunol 2001
(Asthma...) :
The transcription factors
GATA-3 and cMAF
mediate IL-4 and IL-5 synthesis, whereas signal transducer and activator of transcription 6 ( STAT-6 ) is critical for IL-4R signaling
Lee et al., Immunity 2001
:
Regulation of
IL-4 gene expression by distal regulatory elements and
GATA-3 at the chromatin level ...
GATA-3 mediated strong enhancement of
IL-4 promoter activity in Th1 cells when the promoter was embedded in the minilocus or linked to HSS and IE, demonstrating that GATA-3 acts through these elements to regulate IL-4 gene expression
Yin et al., J Immunol 2002
:
These results indicate that T-bet enhances IFN-gamma secretion and
suppresses IL-4 secretion in gammadelta cells, and that
GATA-3 fails to counterbalance T-bet mediated IFN-gamma production, accounting for the default synthesis of IFN-gamma by these T lymphocytes
Höfer et al., Proc Natl Acad Sci U S A 2002
:
Based on these experimental data, we developed a mathematical model of GATA-3 expression that assumes independent
activation of
GATA-3 transcription by
IL-4 and by GATA-3
Takemoto et al., J Immunol 2002
:
The selective use of the N-finger may underlie the differential
roles of
GATA-3 in the induction of
IL-4 , IL-13, and IL-5
Yagi et al., J Immunol 2003
:
We found a tight correlation among the levels of H4/inducible costimulator (ICOS) expression,
IL-4 production, and
GATA-3 induction , using activated CD4 ( + ) T cells obtained from six different murine strains
Wurtz et al., Int Immunol 2004
:
We further show that the difference in IL-4 responsiveness correlates with a loss, in effector Th1 cells, of
IL-4 dependent up-regulation of
GATA-3 expression despite normal activation of STAT6
Seki et al., J Immunol 2004
:
IL-4 induced
GATA-3 expression is a time restricted instruction switch for Th2 cell differentiation ... At later times, however, IL-4 failed to promote efficient Th2 differentiation and decondensation of chromatin, even though
GATA-3 was clearly
induced in the nuclei by
IL-4 stimulation ... These results demonstrate that
IL-4 induced
GATA-3 expression is time-restriction switch for Th2 differentiation
Kaminuma et al., FEBS Lett 2004
:
IL-4 expression was reciprocally
affected by
GATA-3
Yamashita et al., J Biol Chem 2004
:
Interleukin (IL)-4 induced STAT6 activation and the subsequent up-regulation of
GATA3 are crucial for the induction of chromatin remodeling of the Th2 cytokine gene loci as Th2 cells undergo development
Li et al., Zhonghua Er Bi Yan Hou Ke Za Zhi 2004
(Rhinitis, Allergic, Perennial) :
GATA-3 contributed to the production of
IL-4 , IL-5 in patients with allergic rhinitis
Kwan et al., Eur J Immunol 2005
:
An intron
GATA binding site regulates chromatin accessibility and is
essential for
IL-4 gene expression in mast cells
Nath et al., J Immunol 2005
(Encephalomyelitis, Autoimmune, Experimental...) :
Treatment of PLP ( 139-151 ) -specific T cells in vitro with AICAR decreased their expression of T-bet in response to IL-12, a Th1 transcription factor, whereas in
response to
IL-4 , it induced the expression and phosphorylation of Th2 transcription factors
GATA3 and STAT6, respectively
Yamashita et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
Interleukin-4 induces STAT6 activation and subsequent
GATA3 transcription
Yamane et al., J Exp Med 2005
:
Here, we provide evidence that early
IL-4 production by naive CD4+ T cells stimulated with cognate peptide
requires TCR induced early
GATA-3 expression and IL-2 receptor signaling, both of which are controlled by the degree of activation of extracellular signal regulated kinase ( ERK )
Schwenger et al., Biochemistry (Mosc) 2005
:
Transcription factor
GATA-3 is
involved in repression of promoter activity of the human
interleukin-4 gene ... The findings suggest a direct
involvement of
GATA-3 in regulation of the human
IL-4 gene transcription as a repressor of the promoter activity
Wang et al., J Immunol 2006
:
GATA-3 strongly
activated IL-4 , IL-5, and IL-13 expression in conventional T cells but had comparatively weak effects on these cytokines in NKT cells
Gregory et al., J Clin Invest 2006
(Encephalomyelitis, Autoimmune, Experimental) :
We propose that
GATA and Ikaros proteins coordinately fine-tune accessibility at the Il4 locus during development to variably
regulate IL-4 expression
Stevens et al., Eur J Immunol 2006
:
Overexpression of
GATA3 by retroviral infection in PKCtheta-deficient T cells
resulted in increased expansion of IL-4 producing T cells and higher
IL-4 production than that of wild type Th2 cells
Dasgupta et al., Mol Pharmacol 2007
(Encephalomyelitis, Autoimmune, Experimental) :
Gemfibrozil consistently inhibited the expression and DNA binding activity of T-bet, a key regulator of interferon-gamma (IFN-gamma) expression and stimulated the expression and DNA binding activity of
GATA3 , a key
regulator of
IL-4
Anthoni et al., International journal of biological sciences 2007
(Asthma...) :
The results indicate that a lack of Smad3 dependent signalling in the normal state will lead to an increase in the
GATA-3 levels and as a
result of this the levels of
IL-4 increase
Barnes et al., Curr Mol Med 2008
(Asthma...) :
In addition
GATA-3 is
essential for the gene expression of the cytokines
IL-4 , IL-5 and IL-13 that mediate allergic inflammation
Filén et al., Mol Cell Proteomics 2009
:
Besides T cell receptor signaling, IL-12 induced STAT4 and T-bet- and
IL-4 induced STAT6 and
GATA3 signaling pathways are the major players regulating the Th1 and Th2 differentiation process, respectively
Cen et al., J Immunol 2009
:
Ectopic expression of
GATA-3 partially
restored IL-4 production by the NKT cells
Notani et al., PLoS Biol 2010
:
In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling,
GATA-3 is downregulated and the expression of signature T ( H ) 2 cytokines such as
IL-4 , IL-10, and IL-13 is
reduced , indicating that Wnt signalling is essential for T ( H ) 2 differentiation
Kemp et al., J Immunol 2010
:
We find overexpression of
GATA-3 restores
IL-4 expression in lck ( -/- ) Th2 cells ; this indicates that the decreased IL-4 expression is due in part to reduced amounts of GATA-3
Apte et al., J Immunol 2010
(Neoplasms, Experimental) :
Tumor derived
IL-4 induced the expression of type 2 cytokines and the transcription factor
GATA-3 by responding CD8 T cells while reducing their CD8 coreceptor expression and ability to eliminate a secondary tumor challenge
Cook et al., J Immunol 2010
:
We show in this study that
IL-4 stimulation
induces GATA-3 mRNA upregulation, but the level of GATA-3 protein induced is insufficient for Th2 differentiation
Lee et al., Life Sci 2011
:
This study suggests that downregulation of
GATA-3 and c-Maf via the suppression of p38, IKK-ß and I?B-a phosphorylation might
contribute to the inhibitory effect of shikonin on mitogen induced
IL-4 and IL-5 production in EL-4T cells
Guerau-de-Arellano et al., Brain 2011
(Encephalomyelitis, Autoimmune, Experimental...) :
These effects were mediated by direct suppression of B lymphoma Mo-MLV insertion region 1 homolog ( BMI1 ) and
interleukin-4 (IL4) expression, resulting in decreased
GATA3 levels , and a Th2 to Th1 cytokine shift
Li et al., PloS one 2012
:
The addition of adiponectin
increased IL-4 production by the T cell line EL4 with augmented nuclear
GATA-3 and phospho-STAT6 expression which were suppressed by knockdown of adiponectin receptor 1 and 2
Jia et al., J Immunol 2013
(Inflammation...) :
During the initial stage,
IL-4 suppressed T-bet and induced
GATA3 expression, characterized by enhanced activating histone modifications and RNA polymerase II (Pol II) recruitment to the GATA3 locus ... However, enhanced IL-13 transcription only occurred at a later stage after TCR stimulation, indicating that
IL-4 induced
GATA3 recruitment poises the IL-13 locus for TCR mediated transcription
Zhang et al., J Immunol 1998
:
Here, we show that ectopic expression of
GATA-3 is
sufficient to drive IL-5 but not
IL-4 gene expression
Ouyang et al., Immunity 1998
:
Here, we show that loss of
GATA-3 expression by developing Th1 cells requires IL-12 signaling through Stat4 and does not simply
result from an absence of
IL-4