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BCL2 — PIK3CA

Text-mined interactions from Literome

Honda et al., J Neurosci Res 2001 (Alzheimer Disease...) : Furthermore, 17beta-estradiol induced phosphorylation of the cAMP response element binding protein ( CREB ) at Ser ( 133 ) within 15 min and then upregulated Bcl-2 in a PI3-K/Akt dependent manner
Bernabé et al., Exp Cell Res 2001 (MAP Kinase Signaling System) : Thus, we propose that exposure to apoptotic concentrations of NO triggers ERK- and p38 dependent cytochrome c release, caspase 3 activation, and PI3K dependent Bcl-2 phosphorylation
Barata et al., Leukemia & lymphoma 2005 (Leukemia-Lymphoma, Adult T-Cell) : PI3K signaling is required for the induction of Bcl-2 , the down-regulation of p27 ( kip1 ) and cell cycle progression
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007 : We thus hypothesized that PI3 K inhibits the activation of caspase-3 and consequent cleavage of Bcl-xL
Iwase et al., Int J Oncol 2007 (Carcinoma, Squamous Cell...) : Expression of Bcl-2 , cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and X-linked IAP was down-regulated, and expression of Bax was up-regulated by PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Lim et al., J Neurosci Res 2008 : Thus, MAPK/ERK dependent p35 up-regulation and MAPK/ERK dependent and PI3K/Akt dependent Bcl2 up-regulation contribute to BDNF stimulated neural differentiation and to the survival of differentiated cells
Creson et al., J Mol Neurosci 2009 (MAP Kinase Signaling System...) : Evidence for involvement of ERK, PI3K , and RSK in induction of Bcl-2 by valproate
Zhang et al., Exp Brain Res 2009 : The importance of the PI3K pathway was further confirmed by the activation of Akt and anti-apoptotic Bcl-2 by cryptotanshinone in a PI3K dependent manner
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of PI3K also suppressed SEK-1/MKK-4 and JNK activation, Bax and Bak activation, and Bcl-2 down-regulation
Elsegood et al., Arterioscler Thromb Vasc Biol 2009 : MEK1/2 and PI3K activities were also required for oxLDL induced Bcl-2 and Bcl-x ( L ) mRNA upregulation
Chang et al., Biochem J 2009 (Ovarian Neoplasms) : Thus mesothelin can inhibit paclitaxel induced cell death mainly by involving PI3K signalling in the regulation of Bcl-2 family expression
Wang et al., Cancer Lett 2010 (Ovarian Neoplasms) : Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and XIAP ), as well as activation of Ras/MEK/ERK and PI3K/Akt signaling
Bratton et al., Int J Oncol 2010 (Breast Neoplasms) : Regulation of ERalpha mediated transcription of Bcl-2 by PI3K-AKT crosstalk : implications for breast cancer cell survival
Beaulieu et al., PloS one 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The effect of a-linolenic acids seemed to be due to PI3K pathway and Bcl-2 inhibition
Wang et al., Toxicol Lett 2013 (Cardiovascular Diseases) : In addition, the PI3K inhibitor partially blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression ... In addition, the PI3K inhibitor partially blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression
Rahmani et al., Cancer Res 2013 (Leukemia, Myeloid) : PI3K/mTOR inhibitors markedly downregulated Mcl-1 but increased Bim binding to Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737 ... PI3K/mTOR inhibitors markedly downregulated Mcl-1 but increased Bim binding to Bcl-2/Bcl-xL ; the latter effect was abrogated by ABT-737
Shukla et al., Neurotoxicology 2013 : Sal toxicity coincided with reduced pAkt level and its downstream effectors : pCREB, pGSK-3ß, Bcl-2 and neurotrophins GDNF, BDNF suggesting repressed PI3K/Akt signaling