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TAF9 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53/Cbp/p300/CARM1/PRMT1 (tetramer) complex (TP53-EP300_CREBBP-CARM1-PRMT1) (transcription, activates)
  An et al., Cell 2004, Gamper et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
  Le Cam et al., Cell 2006, Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, el-Deiry et al., Cancer Res 1995
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
  Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Tang et al., Cell 2008, el-Deiry et al., Cancer Res 1995
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
  Nakano et al., Mol Cell 2001, Koutsodontis et al., Biochem J 2005, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Gamper et al., Mol Cell Biol 2008, Jansson et al., Nat Cell Biol 2008
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
  Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Jansson et al., Nat Cell Biol 2008, el-Deiry et al., Cancer Res 1995
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: GCN5-L/ADA2B/TAF9 complex (KAT2A-TADA2B-TAF9) → p53 (tetramer) complex (TP53) (transcription, activates)
  Nakano et al., Mol Cell 2001, Koutsodontis et al., Biochem J 2005, Wu et al., Cell 2005, Tang et al., Mol Cell 2006, Sykes et al., Mol Cell 2006, Shi et al., Mol Cell 2007, Gamper et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TAF9 — TP53 (physical association, affinity chromatography technology) Buschmann et al., J Biol Chem 2001*
• IRef Biogrid Interaction: TAF9 — TP53 (physical association, affinity chromatography technology) Gamper et al., Mol Cell Biol 2008
• IRef Biogrid Interaction: TAF9 — TP53 (direct interaction, pull down) Lu et al., Proc Natl Acad Sci U S A 1995*
• IRef Ophid Interaction: TAF9 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Buschmann et al., J Biol Chem 2001 : In this report, we demonstrate that expression of TAF(II)31 inhibits mdm2 mediated ubiquitination of p53 and increases p53 levels ... Our results suggest that direct interaction of TAF(II)31 and p53 not only mediates p53 transcriptional activation but also protects p53 from mdm2 mediated degradation, thereby resulting in activation of p53 functions
Li et al., Mol Cell 2009 : We further demonstrate that MOF-MSL1v1 is specifically required for optimal transcription activation of p53 target genes both in vitro and in vivo
Chen et al., Genes Dev 1993 : Surprisingly, both TBP and TFIID also stimulate p53 binding to DNA containing a specific p53 binding site but lacking a TATA box