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IL6 — TYK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL6-mediated signaling events: PTPEC (PTPRE) → IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) (modification, inhibits)
  Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) (modification, collaborate)
  Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA complex (IL6-IL6R) → gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4) (modification, collaborate)
  Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4) → gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4) (modification, collaborate)
  Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
  Evidence: mutant phenotype, physical interaction, other species

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Tanuma et al., J Biol Chem 2000 (Leukemia, Myeloid, Acute) : PTPepsilonC expression resulted in lower levels of IL-6 induced tyrosine phosphorylation of Jak1, Tyk2 , gp130, and Stat3 compared with parent cells
Kunioku et al., Neurosci Lett 2001 : A Janus tyrosine kinase 2 inhibitor ( tyrphostin AG490 ) suppressed the phosphorylation of signal transducers and activators of transcription ( STAT ) 3 and only partially inhibited the anti-apoptotic activity of IL-6
Soth et al., J Med Chem 2013 : Evaluation of this analogue in cellular and in vivo models confirmed functional selectivity for modulation of a JAK3/JAK1 dependent IL-2 stimulated pathway over a JAK1/JAK2/Tyk2 dependent IL-6 stimulated pathway