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CSF3 — NOS2
Text-mined interactions from Literome
Deetjen et al., Immunopharmacology 1999
:
Qualitative and quantitative analyses of iNOS cDNA revealed that
G-CSF significantly
reduced interferon-gamma/lipopolysaccharide ( IFN-gamma/LPS ) dependent
iNOS gene expression ( P < 0.05 ) following 6, 18, 24, and 48 h incubation periods
Stephan et al., Int J Tissue React 1999
:
However, both IL-1 beta and G-CSF caused a significant increase ( p < 0.05 ) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production
induced by
G-CSF and this implicated
nitric oxide synthase activity
Hierholzer et al., Am J Physiol Gastrointest Liver Physiol 2004
(Enteritis...) :
Selective
iNOS inhibition in shocked animals reduced the binding activity of NF-kappaB and Stat3 and
reduced mRNA levels of ICAM-1, IL-6, and
G-CSF
Wai et al., Surgery 2006
(Adenocarcinoma...) :
In our system of CT26-RAW264.7 coculture, we conclude that inhibition of OPN synthesis in CT26 results in
G-CSF mediated induction of macrophage
iNOS expression with resultant inhibition of CT26 proliferation via increased apoptosis
Oppeltz et al., Cytokine 2012
(Burns) :
Inhibition of
iNOS activity in WT mice with L-Nil
suppressed burn wound levels of IL-1ß,
G-CSF , and MIP-1a, whereas IL-6, TNF-a, KC, MCP-1 and MIP-1ß were unaffected
Squadrito et al., Br J Pharmacol 1997
(Mesenteric Vascular Occlusion...) :
Finally rh
G-CSF potently
inhibited the activity of inducible
nitric oxide synthase in peritoneal macrophages activated with endotoxin
Squadrito et al., Int J Microcirc Clin Exp 1997
(Acute Disease...) :
Finally, rh
G-CSF inhibited the activity of inducible
nitric oxide synthase in peritoneal macrophages activated with endotoxin
Hierholzer et al., J Exp Med 1998
(Inflammation...) :
Using the iNOS inhibitor N6- ( iminoethyl ) -L-lysine or iNOS knockout mice we found that the activation of the transcriptional factors nuclear factor kappaB and signal transducer and activator of transcription 3 and increases in IL-6 and
G-CSF messenger RNA levels in the lungs and livers measured 4 h after resuscitation from hemorrhagic shock were
iNOS dependent
Hoffmann et al., Eur J Pharmacol 1998
:
Granulocyte-colony stimulating factor inhibits inducible
nitric oxide synthase gene expression in pulmonary epithelial cells in vitro ... We show that
G-CSF suppresses interferon-gamma/tumor necrosis factor-alpha (TNF-alpha)
induced inducible
nitric oxide synthase gene expression detected as inducible nitric oxide synthase cDNA ( cDNA concentration was 633 +/- 38 amol/microg total RNA following 24 h incubation with 100 U/ml interferon-gamma/500 U/ml TNF-alpha, and 440 +/- 14 amol/microg total RNA following 24 h incubation with 250 U/ml G-CSF +/- 100 U/ml interferon-gamma/500 U/ml TNF-alpha, respectively )