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CIITA — IRF6

Text-mined interactions from Literome

Xi et al., Oncogene 2001 : In addition to IRF-1, IRF-2 , another member of the IRF family, also activates the human CIITA type IV promoter, and IRF-2 cooperates with IRF-1 to activate the promoter in transient transfection assays
Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : In DC, the inhibitory effect of LPS on CIITA expression was prevented by MyD88 deficiency or pharmacological MAPK inhibitors specific for MEK ( U0126 ) and p38 ( SB203580 ), but not JNK ( SP600125 ) ... In macrophages, LPS inhibited IFN-gamma-inducible CIITA and MHC class II expression without affecting expression of IFN regulatory factor-1 and MHC class I. Blocking ERK and p38 by MAPK inhibitors not only rescued LPS mediated inhibition, but also augmented IFN-gamma induction of CIITA
Casals et al., J Immunol 2007 : LPS does not enhance the expression of the transactivator CIITA