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IL8 — MPO
Text-mined interactions from Literome
Krupa et al., Am J Physiol Lung Cell Mol Physiol 2004
(Pulmonary Edema...) :
Anti-IL-8 :
IL-8 complexes
triggered superoxide and
myeloperoxidase release from human neutrophils, and in contrast, the control antibody had no effect
Hsieh et al., Clin Rheumatol 2007
:
The spontaneous membrane expression of
MPO and PR3 on PMN could be significantly
increased by lipopolysaccharide (LPS) and TNF-alpha, but not by
IL-8 or GRO-alpha
Biju et al., Bioorg Med Chem Lett 2008
:
A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-alpha and
IL-8 mediated in vitro hPMN
MPO release of CXCR2 and CXCR1 expressing cell lines
Haegens et al., Eur Respir J 2008
:
Interestingly,
MPO inhibited
IL-8 production in bronchial, but not alveolar epithelium ... In addition,
myeloperoxidase inhibited
interleukin-8 production by bronchial epithelial cells, indicating a negative feedback loop for neutrophil recruitment
Niu et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2010
(Disease Models, Animal...) :
The levels of IL-8 and
MPO increased significantly in the IRI group [
IL-8 : ( 812+/-26 ) ng/L vs. ( 72+/-13 ) ng/L, MPO : ( 78.7+/-2.9 ) kU/L vs. ( 13.3+/-1.5 ) kU/L, both P < 0.01 ]
Wang et al., Transplant Proc 2010
(Brain Death...) :
Biliverdin reversed the aggravation of Pa ( O ( 2 ) ) in recipients, reduced the grafts wet/dry ratio, decreased the severity of lung injury measured by histologic examination, reduced serum tumor necrosis factor-alpha and
interleukin-8 levels and
inhibited myeloperoxidase activity (MPO) in the grafts
Samanta et al., J Biol Chem 1993
:
At a concentration of 0.4 mM, N-ethylmaleimide reduced the
IL-8 induced ( 10 micrograms/ml ) release of
myeloperoxidase by 50 %
Segura et al., Am J Respir Crit Care Med 1998
(Pleural Effusion) :
Our results indicate that local production of markers of the nonspecific inflammatory response is high in both chronic and acute pleural infection, and suggest a
role for
IL-8 in the release of NE and
MPO