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GPI — PTH

Text-mined interactions from Literome

Sugimoto et al., J Cell Physiol 1992 (Bone Neoplasms...) : Both human ( h ) PTH- ( 1-34 ) and hPTHrP- ( 1-34 ) caused a progressive decrease in pHi and the inhibition of [ 3H ] thymidine incorporation ( TdR ) to the same degree in a dose dependent manner with a minimal effective dose of 10 ( -10 ) M. Dibutyryl cAMP ( 10 ( -4 ) M and Sp-cAMPS ( 10 ( -4 ) M ), a direct stimulator of PKA also caused a progressive decrease in pHi, and calcium ionophores ( A23187 and ionomycin, 10 ( -6 ) M ) caused a transient decrease in pHi ... In the presence of amiloride, PTH and PTHrP caused a transient decrease in pHi , which was similar to the pattern of calcium ionophore induced change in pHi
Michnowska et al., Am J Nephrol 1996 : Effects of parathyroid hormone on hepatocyte pHi and Na ( + ) -H+ exchanger activity ... PTH also caused a progressive rise in hepatocyte pHi which became apparent after the initial activation of the Na ( + ) -H+ antiport ... Also, PTH may facilitate a Ca2+/2H+ exchange across the hepatocyte membrane and causes an initial and persistent rise in pHi , since the rise in pHi occurred under conditions where Na ( + ) -H+ antiport is inactive ( potassium media )