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OSM — PTGS2

Text-mined interactions from Literome

Pourtau et al., FEBS Lett 1999 : We conclude that induction of COX-2 by OSM is necessary for its angiogenic activity, but is not sufficient since IL-1beta, which also induces COX-2 in HMEC-1, has only a poor proliferative effect
Bernard et al., Circ Res 1999 : Oncostatin M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta ... OSM induced marked expression of COX-2 protein and mRNA ... Interestingly, OSM acted in synergy with IL-1beta on IL-6 production and COX-2 expression
Lahiri et al., Am J Physiol Lung Cell Mol Physiol 2001 : IL-6, IL-11, and OSM alone had no effect on COX-2 expression ... However, OSM caused dose dependent augmentation of COX-2 expression and prostaglandin ( PG ) E ( 2 ) release induced by IL-1beta ... In addition, OSM and IL-1beta synergistically cause COX-2 expression and PGE ( 2 ) release
Repovic et al., Glia 2003 (Astrocytoma...) : Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase-2 in astrocytes : synergy with interleukin-1beta, tumor necrosis factor-alpha, and bacterial lipopolysaccharide