Chen et al., Dev Cell 2010
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Thus, under stress conditions, FoxO inhibits the anabolic activity of mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Melnik et al., Exp Dermatol 2013
:
This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1