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IL1A — PTK7

Text-mined interactions from Literome

Chen et al., Mol Pharmacol 2000 : Taken together, IL-1beta activates phosphatidylcholine-specific phospholipase C and induces activation of PKCalpha and protein tyrosine kinase , resulting in the stimulation of NIK, IKK2, and NF-kappaB in the ICAM-1 promoter, then initiation of ICAM-1 expression
Geng et al., J Cell Physiol 1995 (Second Messenger Systems) : The protein tyrosine kinase ( PTK ) inhibitors herbimycin A or genistein reduced IL-1 or LPS induced NO release and NOS enzymatic activity
Adamson et al., Cell adhesion and communication 1996 : However when PTK inhibitors were present during both agonist activation ( 2h ) and subsequent expression of E-selectin after removal of agonist ( 4h ) the PTK inhibitors resulted in a dose dependent reduction in both IL-1 alpha and LPS stimulated E-selectin expression ( IC50 = 50M ) ... Moreover when PTK inhibitors were only incubated with cells for the 4h after cytokine or LPS activation of cells, PTK inhibitors resulted in a more effective dose dependent reduction in IL-1 alpha or LPS stimulated E-selectin expression ( IC50 = 10M )
Kong et al., Neurochem Int 1997 : This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS) induced production of TNF alpha, IL-1 alpha , and IL-6 in mouse primary mixed glia, microglia- or astrocyte enriched cultures