Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CITED2
→
FOXO1
(increases, CITED2 Activity)
Abid et al., J Biol Chem 2006* Evidence: The data revealed the existence of a novel set of VEGF-responsive genes that require FKHR activity for optimal expression in ECs, including bone morphogenic protein 2, cbp/p300-interacting transactivator 2, decay accelerating factor (DAF), vascular cell adhesion molecule-1 (VCAM-1), manganese superoxide dismutase, endothelial-specific molecule-1, RING1 and YY1 binding protein, and matrix metalloproteinase-10 and MGC5618
OpenBEL Selventa BEL large corpus:
CITED2
→
FOXO1
(increases, CITED2 Activity)
Modur et al., J Biol Chem 2002* Evidence: Mutations in PTEN occur in 60-80% of prostate cancers and lead to a constitutive activation of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of PTEN mutations in prostate cancer, we used microarrays to identify genes regulated by FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 p...