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GAL — TLR2

Text-mined interactions from Literome

Kammanadiminti et al., FASEB J 2004 : Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolytica ... The mechanism whereby the Gal-lectin regulates Toll-like receptor 2 (TLR-2) expression in macrophages was studied ... Native Gal-lectin increased TLR-2 mRNA expression in a dose- and time dependent fashion ; peak response occurred with 1 microg/ml after 2 h stimulation ... The Gal-lectin increased TLR-2 gene transcription, and the half-life of the mRNA transcripts was 1.4 h. Inhibition of nuclear factor (NF)-kappaB suppressed TLR-2 mRNA induction by the Gal-lectin
Darmoise et al., Immunity 2010 : Thus, we present TLR dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for NKT cells