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IL27 — JAK1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL27-mediated signaling events:
gp130 (IL6ST)
→
IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1)
(modification, collaborate)
Pflanz et al., Immunity 2002, Takeda et al., J Immunol 2003, Pflanz et al., J Immunol 2004
Evidence: physical interaction, other species, functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1)
→
IL27/EBI3 complex (IL27-EBI3)
(modification, collaborate)
Pflanz et al., Immunity 2002, Takeda et al., J Immunol 2003, Pflanz et al., J Immunol 2004
Evidence: physical interaction, other species, functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1)
→
IL27RA/JAK1 complex (IL27RA-JAK1)
(modification, collaborate)
Pflanz et al., Immunity 2002, Takeda et al., J Immunol 2003, Pflanz et al., J Immunol 2004
Evidence: physical interaction, other species, functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
IL27/EBI3 complex (IL27-EBI3)
→
IL27RA/JAK1 complex (IL27RA-JAK1)
(modification, collaborate)
Pflanz et al., Immunity 2002, Takeda et al., J Immunol 2003, Pflanz et al., J Immunol 2004
Evidence: physical interaction, other species, functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
STAT1 (STAT1)
→
IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1)
(modification, collaborate)
Takeda et al., J Immunol 2003
Evidence: physical interaction, other species
-
NCI Pathway Database IL27-mediated signaling events:
IL27/IL27R/JAK1 complex (IL27-EBI3-IL27RA-IL6ST-JAK1)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Takeda et al., J Immunol 2003
Evidence: physical interaction, other species
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis