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CDX2 — WNT6
Text-mined interactions from Literome
Guo et al., J Biol Chem 2004
(Colonic Neoplasms) :
Finally, we show that colon cancer cells effectively reduce
Cdx2 mediated inhibition of
Wnt/beta-catenin/TCF transcriptional activity when compared with other model systems
Guo et al., Carcinogenesis 2010
(Colonic Neoplasms) :
Considering the pivotal role of beta-catenin/TCF activity in driving proliferation of normal intestinal epithelial and colon cancer cells, our findings suggest a novel mechanism for
Cdx2 mediated regulation of
Wnt/beta-catenin signaling and cell proliferation
Beschorner et al., Histol Histopathol 2009
(Choroid Plexus Neoplasms) :
In the intestine,
Wnt signaling
represses the expression of the tumor suppressor gene
CDX2 via SOX9, a transcription factor, which is also expressed in the choroid plexus
Crissey et al., Gastroenterology 2011
(Malabsorption Syndromes) :
Cdx2 regulates intestinal cell-cell adhesion, proliferation, and the transcriptional activities of
Wnt and ß-catenin in cell culture systems
Liu et al., Cancer Biol Ther 2012
(Lung Neoplasms...) :
CDX2 may serve as a tumor suppressor in lung cancer and inhibits lung cancer cell proliferation by
suppressing Wnt signaling