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IL6 — LIF

Text-mined interactions from Literome

Knight et al., Am J Respir Cell Mol Biol 1999 : The present study aimed to determine the cellular distribution and regulation of gene transcripts for LIF and LIFR in human lung, and measured the release of LIF in response to anti-immunoglobulin ( Ig ) E, interleukin (IL)-1beta , and IL-6 ... IL-6 also induced the expression of LIF mRNA and release of LIF in airway smooth-muscle cells, whereas exogenous LIF itself had no effect
Ren et al., J Clin Endocrinol Metab 1999 (Hypothyroidism) : TSH ( 100 mIU/mL ) and interleukin (IL)-6 ( 10 nmol/L ) stimulated in vitro LIF secretion from the cells by 170+/-12 % ( P < 0.05 ) and 261+/-8 % ( P < 0.05 ), respectively ... Dexamethasone ( 1 micromol/L ) inhibited basal LIF concentration by 83 % ( P < 0.05 ), whereas TSH and IL-6 stimulated LIF by 52 % ( P = 0.04 ) and 42 % ( P = 0.03 ), respectively
Nan et al., J Comp Neurol 2001 : These data indicate that LIF from infiltrating macrophages acts as a mitogen for GBCs and that LIF from infiltrating macrophages and IL-6 from infiltrating macrophages and ensheathing cells act as repair factors in the ON
Kozawa et al., Cell Signal 2002 : Leukemia inhibitory factor enhances bFGF induced IL-6 synthesis in osteoblasts : involvement of JAK2/STAT3 ... In the present study, we investigated the effects of leukemia inhibitory factor (LIF) on the release of VEGF and IL-6 in these cells ... On the contrary, LIF , which alone had little effect on IL-6 release, significantly enhanced the bFGF stimulated IL-6 release ... The amplifying effect of LIF on the IL-6 release was dose dependent in the range between 0.01 and 10 ng/ml. AG490, an inhibitor of JAK2, suppressed the amplifying effect of LIF ... Taken together, our results strongly suggest that LIF enhances bFGF stimulated IL-6 synthesis via JAK2/STAT3 pathway in osteoblasts
Tofaris et al., J Neurosci 2002 (Neurilemmoma) : Furthermore, IL-6 rapidly induced LIF mRNA in primary Schwann cells, and LIF rapidly induced MCP-1 mRNA expression
Wang et al., J Biol Chem 2003 (Acute Disease...) : They also demonstrate that LIF induces IL-6 and that the protective effects of LIF are mediated, in part, via this inductive event
Gruss et al., Blood 1992 : Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia inhibitory factor ... Recent studies have indicated that the leukemia inhibitory factor (LIF) induces secretion of interleukin-6 (IL-6) in myeloid cells ... Deletion of the NF-kappa B binding site in the IL-6 promoter was associated with loss of inducibility by LIF, lending further support for the notion that the NF-kappa B binding site is crucial for LIF mediated induction of the IL-6 promoter
Yamaguchi et al., J Biol Chem 1992 (Leukemia, Myelomonocytic, Acute) : We examined the effect of leukemia inhibitory factor (LIF) on the expression of interleukin 6 receptors (IL-6R) on mouse myelomonocytic leukemic M1 cells ... Binding studies using 125I labeled human and murine IL-6 revealed that LIF caused a decrease in IL-6 binding to M1 cells ... The decrease became evident within 1 h, and the maximum decrease was observed at 3-6 h. Scatchard plot analysis revealed that M1 cells had a single class of high affinity receptors for IL-6 and that LIF induced decrease in IL-6 binding was due to a decrease in the number of IL-6R on the cell surface and not to changes in their affinity
Perrier d'Hauterive et al., Journal de gynécologie, obstétrique et biologie de la reproduction 2004 : HCG and TGFbeta1 added to primary cultures of human epithelial endometrial cells showed a stimulatory effect on LIF secretion and a reducing effect on IL-6 secretion
Persson et al., Biochem Biophys Res Commun 2005 : The IL-6 protein release from calvarial osteoblasts was also stimulated by the osteoclastogenic, proinflammatory cytokines IL-11, LIF , OSM, IL-17, TGF-beta, and TNF-alpha
Gascan et al., Lymphokine Cytokine Res 1991 (Lymphoma, T-Cell) : Induction of leukemia inhibitory factor secretion by interleukin-1 in a human T lymphoma cell line
Gao et al., Cell cycle (Georgetown, Tex.) 2009 : In striking contrast, we found that IL6 effectively inhibited LIF signalling, repressing transcription of the LIF receptor gp190, and strongly inducing axotrophin/MARCH-7, a novel E3 ubitquitin ligase that we discovered to be active in degradation of gp190 protein
Mori et al., Int Immunol 2011 (Arthritis, Experimental...) : Leukemia inhibitory factor expression and STAT3 activation by IL-1ß were mainly promoted by IL-6 but still induced in IL-6-deficient cells
Shuya et al., PloS one 2011 : LIF ( 50 ng/ml ) up-regulated IL6 and IL15 ( P < 0.05 ) secretion in decidualized HESC compared to 0.5 ng/ml LIF
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : In the absence of sIL-6R, IL-6 did not induce STAT1/3 phosphorylation, whereas IL-6/sIL-6R and LIF induced STAT1 and STAT3 phosphorylation
Metcalf et al., Leukemia 1989 (Leukemia, Experimental...) : M1 cells constitutively produced low levels of IL-6 and production was enhanced by LIF , but the general characteristics of the actions of LIF, IL-6, and G-CSF suggested that each operates independently as a direct differentiation inducer of leukemic cells
Jonakait et al., Trends Neurosci 1993 : Glucocorticoid hormones block the interleukin-1 induction of leukemia inhibitory factor , which explains why they block the interleukin-1 induction of substance P
Arici et al., J Clin Endocrinol Metab 1995 : On the other hand, we showed that interleukin-1 , tumor necrosis factor-alpha, platelet derived growth factor, epidermal growth factor, and transforming growth factor-beta are potent inducers of LIF expression in endometrial stromal cells in culture in a concentration- and time dependent manner
Hartner et al., Kidney Int 1994 : LIF itself or IL-6 had no effect on LIF mRNA expression
Aloisi et al., J Immunol 1994 : LIF synthesis was significantly increased by the cytokines IL-1 beta, TNF-alpha, and TGF-beta 1, but not by IFN-gamma, IL-6 , or LPS
Bagnara et al., Stem Cells 1993 (Fanconi Anemia) : A significant decrease of IL-6 was detected in 9 out of 11 FA patients compared with five normal donors, while similar amounts of LIF were produced from 21 FA patients and 21 healthy subjects
Villiger et al., J Clin Invest 1993 : Recombinant human LIF increases levels of IL-1 beta, IL-6 , and IL-8 mRNA in human articular chondrocytes as demonstrated by Northern blotting ... By metabolic labeling and immunoprecipitation it is shown that LIF induces synthesis and secretion of IL-6 ... In addition to increased mRNA expression, LIF also stimulates release of biologically active IL-6 from blood monocytes ... In synoviocytes and neuronal as well as epithelial cell lines, LIF increases IL-1 beta and IL-6 gene expression
Henrotin et al., Osteoarthritis Cartilage 1996 : IL-6 decreased IL-8 synthesis and increased LIF production ... Finally, LIF stimulated IL-1 beta, IL-6 and IL-8 productions
Sawai et al., Biol Reprod 1997 : Stimulation of decidual cells by interleukin-1 , tumor necrosis factor alpha, or transforming growth factor beta augmented LIF production in a dose dependent manner
Van de Loo et al., Cytokine 1997 : We studied the role of IL-6 and nitric oxide ( NO ) in IL-1 and leukaemia inhibitory factor (LIF) induced suppression of proteoglycan synthesis
Lorgeot et al., Cytokine 1997 : Interleukin 1alpha (IL-1alpha), IL-1beta, IL-3, IL-6 , IL-8, tumour necrosis factor ( TNF-alpha ) and SCF ( both at 10 ng/ml ) stimulate LIF production
Nicholson et al., EMBO J 1999 : SOCS-1 and SOCS-3 inhibited both interleukin-6 (IL-6)- and leukemia inhibitory factor (LIF) induced macrophage differentiation of murine monocytic leukemic M1 cells and LIF induction of a Stat3-responsive reporter construct in 293T fibroblasts