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IL6 — TGFB2
Text-mined interactions from Literome
Sayah et al., J Neurochem 1999
(Astrocytoma) :
Whereas IL-1beta, tumor necrosis factor-alpha, and
transforming growth factor-beta mRNA levels remained unchanged, stimulation of astrocytoma cells ( T98G, CB193, U118MG ) by C3a, C5a, and peptidic C3aR and C5aR agonists
induced an increase in the
IL-6 mRNA level
Chen et al., J Biol Chem 1999
(Carcinoma, Hepatocellular...) :
Interleukin-6 inhibits
transforming growth factor-beta induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
Lyons et al., Infect Immun 2001
(Chronic Disease...) :
Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and
transforming growth factor beta and a protective
role for
interleukin-6
Penkowa et al., J Neurosci Res 2003
(Disease Models, Animal...) :
Also,
IL-6 induced significant
increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF),
transforming growth factor-beta , neurotrophin-3, angiopoietin, vascular endothelial growth factor, and the receptor for bFGF
Bry et al., Am J Obstet Gynecol 1992
(Obstetric Labor, Premature) :
Human amnion cells in monolayer culture were treated with
interleukin-1 , tumor necrosis factor, or vehicle in the
presence or absence of
transforming growth factor-beta
Musso et al., J Immunol 1992
:
We have previously reported that
transforming growth factor-beta inhibits
IL-6 production in response to IL-1 beta
Layh-Schmitt et al., Curr Opin Rheumatol 2008
(Spondylarthropathies) :
In mice,
transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages
promoting interleukin-17 production
Kitani et al., Mucosal Immunol 2008
:
It is now well established that although
transforming growth factor ( TGF ) -beta alone induces FoxP3 ( + ) regulatory T ( Treg ) cells, TGF-beta and
interleukin (IL)-6 , acting in concert,
induce differentiation of mouse naive T cells into Th17
Musso et al., Blood 1990
:
We investigated the
effects of
transforming growth factor beta ( TGF beta ) on the induction by interleukin-1 beta (IL-1 beta) of
IL-6 in human monocytes
Espevik et al., Cell Immunol 1990
:
The
effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and
transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and
interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Lagneaux et al., Blood 1993
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Excessive production of
transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia
inhibits growth of hematopoietic precursors and
interleukin-6 production
Möller et al., Exp Dermatol 1994
(Carcinoma, Squamous Cell) :
Therefore, the
regulation of the production of the ubiquitous proinflammatory cytokine
interleukin 6 (IL-6) by
transforming growth factor beta ( TGF beta ) was investigated
Kuppner et al., Immunology 1995
:
We investigated the
effect of
transforming growth factor-beta ( TGF-beta ) on interleukin-1 beta (IL-1 beta) induction of
IL-6 and IL-8 mRNA levels and protein production by human RPE cells
Matsuzaki et al., Nihon Sanka Fujinka Gakkai Zasshi 1994
(Chorioamnionitis) :
However,
transforming growth factor-beta ( TGF-beta )
suppressed these cytokine mediated hCG production as well as
IL-6 production
McGee et al., J Immunol 1993
:
In a previous study,
transforming growth factor-beta ( TGF-beta 1 ) was also found to
enhance IL-6 secretion by the IEC-6 cells and because both IL-1 beta and TGF-beta may be present in inflamed mucosal tissue, the effect of adding both cytokines together was next investigated
Danforth et al., Cancer Res 1993
(Breast Neoplasms) :
IL-1, but not
IL-6 ,
increased secretion of
transforming growth factor-beta ( TGF-beta ) by 2.45-fold over 72 h ( P < 0.01 )
Osawa et al., Nephrol Dial Transplant 1995
:
Secretion of
IL-6 by GECs was
increased by
transforming growth factor beta but not by IL-1 beta
Spittler et al., Immunology 1997
:
Both constitutive and interferon-gamma (IFN-gamma), interleukin-4 (IL-4),
IL-6 and tumour necrosis factor-alpha (TNF-alpha) induced human leucocyte antigen ( HLA ) -DR, HLA-DP and HLA-DQ Ag expression on monocytes was significantly
down-regulated by calcitriol, IL-10 and
transforming growth factor-beta ( TGF-beta )
Marth et al., Eur J Immunol 1997
:
Regulation of
transforming growth factor-beta production by
interleukin-12
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10,
transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra