Gene interactions and pathways from curated databases and text-mining

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IL6 — TGFB2

Text-mined interactions from Literome

Sayah et al., J Neurochem 1999 (Astrocytoma) : Whereas IL-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta mRNA levels remained unchanged, stimulation of astrocytoma cells ( T98G, CB193, U118MG ) by C3a, C5a, and peptidic C3aR and C5aR agonists induced an increase in the IL-6 mRNA level
Chen et al., J Biol Chem 1999 (Carcinoma, Hepatocellular...) : Interleukin-6 inhibits transforming growth factor-beta induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
Lyons et al., Infect Immun 2001 (Chronic Disease...) : Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6
Penkowa et al., J Neurosci Res 2003 (Disease Models, Animal...) : Also, IL-6 induced significant increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF), transforming growth factor-beta , neurotrophin-3, angiopoietin, vascular endothelial growth factor, and the receptor for bFGF
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1 , tumor necrosis factor, or vehicle in the presence or absence of transforming growth factor-beta
Musso et al., J Immunol 1992 : We have previously reported that transforming growth factor-beta inhibits IL-6 production in response to IL-1 beta
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Kitani et al., Mucosal Immunol 2008 : It is now well established that although transforming growth factor ( TGF ) -beta alone induces FoxP3 ( + ) regulatory T ( Treg ) cells, TGF-beta and interleukin (IL)-6 , acting in concert, induce differentiation of mouse naive T cells into Th17
Musso et al., Blood 1990 : We investigated the effects of transforming growth factor beta ( TGF beta ) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes
Espevik et al., Cell Immunol 1990 : The effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Lagneaux et al., Blood 1993 (Leukemia, Lymphocytic, Chronic, B-Cell) : Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production
Möller et al., Exp Dermatol 1994 (Carcinoma, Squamous Cell) : Therefore, the regulation of the production of the ubiquitous proinflammatory cytokine interleukin 6 (IL-6) by transforming growth factor beta ( TGF beta ) was investigated
Kuppner et al., Immunology 1995 : We investigated the effect of transforming growth factor-beta ( TGF-beta ) on interleukin-1 beta (IL-1 beta) induction of IL-6 and IL-8 mRNA levels and protein production by human RPE cells
Matsuzaki et al., Nihon Sanka Fujinka Gakkai Zasshi 1994 (Chorioamnionitis) : However, transforming growth factor-beta ( TGF-beta ) suppressed these cytokine mediated hCG production as well as IL-6 production
McGee et al., J Immunol 1993 : In a previous study, transforming growth factor-beta ( TGF-beta 1 ) was also found to enhance IL-6 secretion by the IEC-6 cells and because both IL-1 beta and TGF-beta may be present in inflamed mucosal tissue, the effect of adding both cytokines together was next investigated
Danforth et al., Cancer Res 1993 (Breast Neoplasms) : IL-1, but not IL-6 , increased secretion of transforming growth factor-beta ( TGF-beta ) by 2.45-fold over 72 h ( P < 0.01 )
Osawa et al., Nephrol Dial Transplant 1995 : Secretion of IL-6 by GECs was increased by transforming growth factor beta but not by IL-1 beta
Spittler et al., Immunology 1997 : Both constitutive and interferon-gamma (IFN-gamma), interleukin-4 (IL-4), IL-6 and tumour necrosis factor-alpha (TNF-alpha) induced human leucocyte antigen ( HLA ) -DR, HLA-DP and HLA-DQ Ag expression on monocytes was significantly down-regulated by calcitriol, IL-10 and transforming growth factor-beta ( TGF-beta )
Marth et al., Eur J Immunol 1997 : Regulation of transforming growth factor-beta production by interleukin-12
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra