Pyagay et al., Circ Res 2005
(Calcinosis...) :
Cthrc1 mRNA expression levels are increased in response to transforming growth factor-beta and bone morphogenetic protein-4
LeClair et al., Trends Cardiovasc Med 2007
(Cardiovascular Diseases) :
Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens ; and regulation or activation of Cthrc1 is strictly controlled in these cells