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NOTCH4 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Laws et al., Eur J Immunol 2004
:
We hypothesize that
p53 regulates
Notch activity during T cell development
Beverly et al., Cancer Res 2005
(Cell Transformation, Neoplastic...) :
Therefore, it is the suppression of p53 that provides the Achilles heel for Notch induced tumors, as activation of
p53 in the
presence of
Notch signaling drives tumor regression
Alimirah et al., Neoplasia (New York, N.Y.) 2007
(Neoplasms) :
Notably,
p53 differentially
regulated the expression of
Notch family members : expression of Notch2 and Notch4 was not induced by p53
Ban et al., Cancer Res 2008
(Sarcoma, Ewing) :
EWS-FLI1 suppresses
NOTCH activated
p53 in Ewing 's sarcoma