Chen et al., Proc Natl Acad Sci U S A 2000
:
In chick mandibles, exogenous bone morphogenetic protein ( BMP ) induces Msx expression and together with fibroblast growth factor promotes the development of Sonic hedgehog expressing epithelial structures
Zhang et al., Development 2002
(Cleft Palate) :
We found that Msx1 expression was restricted to the anterior of the first upper molar site in the palatal mesenchyme and that Msx1 was required for the expression of Bmp4 and Bmp2 in the mesenchyme and Shh in the medial edge epithelium ( MEE ) in the same region of developing palate
Tribulo et al., Development 2003
:
All the results show that a reduction in the level of Bmp activity leads to an increase in the expression of Msx genes in the neural plate border
Liu et al., Dev Biol 2005
:
Furthermore, our data uncovered different Bmp4 thresholds for expression of the Bmp dependent Msx1 and Msx2 genes in mandibular mesenchyme
Binato et al., Biochem J 2006
:
Our results suggest that BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene
Chen et al., J Exp Zool 1998
:
BMPs may in some cases trigger the cell death cascade, while Msx gene products regulate Bmp expression