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IFI27 — PIK3CA

Text-mined interactions from Literome

Riley et al., Oncogene 2001 : This was because reduced PI3-K activity lead to proteolytic degradation of p27
Murillo et al., Endocrinology 2001 (Disease Progression...) : At this stage, PI3K inhibition rapidly triggered accumulation of p27 ( kip1 ), cell cycle arrest, and cell death
Banerji et al., Oncogene 2001 (Lymphoma, B-Cell...) : Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27 ( Kip1 ) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation
van Duijn et al., Prostate 2006 (Prostatic Neoplasms) : PI3K/Akt signaling regulates p27 ( kip1 ) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27 ( kip1 ) regulation in LNCaP and PC346 cells ... In PC3 and DU145 cells, Skp2 is the main determinant in the PI3K/Akt dependent regulation of p27 ( kip1 )
Abramova et al., Tsitologiia 2005 (Cell Transformation, Neoplastic) : Inhibition of PI3K leads to p27 ( Kip1 ) accumulation and cell cycle arrest, consequently
Larrea et al., Mol Cell Biol 2008 : PI3K/PKB inhibition rapidly reduced p27pT157 and p27pT198 and dissociated cellular p27-cyclin D1-Cdk4
Gopinath et al., Mol Oncol 2011 (Glioma) : uPAR and cathepsin B downregulation was recently shown to induce p27 expression through PI3K/Akt/FOXO3a signaling
Brennan et al., Immunity 1997 : Inhibition of PI3K inhibits phosphorylation of Rb, induction of cyclin D3, and degradation of p27kip1