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FAS — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FAS → STAT3 (decreases, FAS Activity)
  Evidence: Downregulation of FAS expression is a common event during tumor progression and has been correlated with resistance to radiation or drug-induced cell death. Importantly, STAT3 binds directly to the FAS promoter in association with JUN to suppress the transcription of the death receptor.
• OpenBEL Selventa BEL large corpus: FAS → Complex of JUN-STAT3 (decreases)
  Evidence: Downregulation of FAS expression is a common event during tumor progression and has been correlated with resistance to radiation or drug-induced cell death. Importantly, STAT3 binds directly to the FAS promoter in association with JUN to suppress the transcription of the death receptor.

Text-mined interactions from Literome

Ivanov et al., J Biol Chem 2002 : Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling
Porras et al., Mol Biol Cell 2004 (MAP Kinase Signaling System) : Phosphorylation of the transcription factor STAT3 on Ser-727, mediated by the extracellular signal regulated kinase MAP kinase pathway, may contribute to the decrease in both Bax and Fas expression in p38 alpha-/- cells
Selvendiran et al., Cancer Res 2006 (Carcinoma, Hepatocellular...) : Consistent with the increased Fas/CD95 expression, a drastic decrease in the Tyr ( 705 ) phosphorylation of STAT3 , a known negative regulator of Fas/CD95 transcription, was found within 20 minutes in the luteolin treated cells, leading to down-regulation in the target gene products of STAT3, such as cyclin D1, survivin, Bcl-xL, and vascular endothelial growth factor