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RAC1 — WASF2
Pathways - manually collected, often from reviews:
-
BioCarta y branching of actin filaments:
WAVE1-3/Nap/PIR/Abl2/HSPC complex (WASF2-NCKAP1-PIR-ABL2-PSMA7)
→
RAC1
(modification, collaborate)
-
BioCarta y branching of actin filaments:
WAVE1-3/Nap/PIR/Abl2/HSPC complex (WASF2-NCKAP1-PIR-ABL2-PSMA7)
→
RAC1/PIR/Abl2/Nap complex (RAC1-PIR-ABL2-NCKAP1)
(modification, collaborate)
-
BioCarta y branching of actin filaments:
RAC1
→
WAVE1-3/HSPC complex (WASF2-PSMA7)
(modification, collaborate)
-
BioCarta y branching of actin filaments:
WAVE1-3/HSPC complex (WASF2-PSMA7)
→
RAC1/PIR/Abl2/Nap complex (RAC1-PIR-ABL2-NCKAP1)
(modification, collaborate)
-
KEGG Adherens junction:
RAC1/RAC2/RAC3
→
Complex of BAIAP2-WASF1-WASF2-WASF3
(protein-protein, activation)
-
KEGG Fc gamma R-mediated phagocytosis:
RAC1/RAC2
→
WASF1/WASF2/WASF3
(protein-protein, activation)
-
KEGG Bacterial invasion of epithelial cells:
RAC1
→
WASF1/WASF2
(protein-protein, activation)
-
KEGG Shigellosis:
RAC1
→
WASF1/WASF2
(protein-protein, activation)
-
Reactome Reaction:
WASF2
→
RAC1
(indirect_complex)
Leng et al., Proc Natl Acad Sci U S A 2005, Suetsugu et al., J Cell Biol 2006, Nakanishi et al., J Biochem 2007, Mendoza et al., Mol Cell 2011, Miki et al., EMBO J 1998
-
Reactome Reaction:
WASF2
→
RAC1
(reaction)
Suetsugu et al., J Cell Biol 2006, Miki et al., EMBO J 1998
Text-mined interactions from Literome
Miki et al., Biochem Biophys Res Commun 2002
:
Interestingly, the intramolecular interaction is interrupted by the binding of WAVE2 and full-length IRSp53 associates with
Rac in the
presence of
WAVE2
Oikawa et al., Nat Cell Biol 2004
:
Production of PtdIns ( 3,4,5 ) P ( 3 ) at the cell membrane by myristoylated phosphatidylinositol-3-OH kinase ( PI(3)K ) is sufficient to recruit
WAVE2 in the
presence of dominant negative
Rac and latrunculin, demonstrating that PtdIns ( 3,4,5 ) P ( 3 ) alone is able to recruit WAVE2
Suetsugu et al., J Cell Biol 2006
:
Purified
WAVE2 and purified WAVE2 complex were activated by IRSp53 in a
Rac dependent manner with PIP ( 3 ) -containing liposomes ... Therefore, IRSp53 optimizes the activity of the
WAVE2 complex in the
presence of activated
Rac and PIP ( 3 )
Harmon et al., PLoS Pathog 2010
(Astrocytoma...) :
Rac and the tyrosine kinase Abl then
activate the
Wave2 complex and promote Arp2/3 dependent actin polymerization