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PCNA — TGFB1
Text-mined interactions from Literome
Choi et al., J Biol Chem 1999
(Liver Neoplasms, Experimental) :
TGF-beta1 induced a transient increase in the expression of Cdc2,
cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis
Wolf et al., Kidney Int Suppl 2000
(Diabetic Nephropathies) :
High glucose,
transforming growth factor-beta ( TGF-beta ), angiotensin II, and probably other factors
induce inhibitors of
cyclin dependent kinases (CDK) including p21Cip1 and p27KiP1
Hashimoto et al., Pancreas 2001
(Carcinoma, Pancreatic Ductal...) :
p21 ( WAF1/CIP1 ), one of the
cyclin dependent kinase (Cdk) inhibitors
induced by
TGF-beta1 , is considered a downstream effector of the growth-inhibitory function of TGF-beta1
Roy et al., Circ Res 2003
(Hyperoxia) :
The molecular signature response to perceived hyperoxia included ( 1 ) induction of p21, cyclin D1, cyclin D2,
cyclin G1, Fos related antigen-2, and transforming growth factor-beta1, ( 2 ) lowered telomerase activity, and ( 3 )
activation of
transforming growth factor-beta1 and p38 mitogen activated protein kinase
Gong et al., Cancer Res 2003
(Adenocarcinoma...) :
TGF-beta 1 inhibited DNA synthesis and
cyclin dependent kinase (CDK) activity after release from growth arrest in association with induction of the p21 CDK inhibitor, whereas cyclins, CDKs, and p27 protein levels remained relatively unchanged
Zhou et al., Endocrinology 2003
:
An inhibitor of
cyclin dependent kinase (cdk) , p15INK4b, was
up-regulated at both transcript and protein levels in these cultures by
TGF-beta1 in a dose related manner as determined by RT-PCR and Western blot analysis
Shi et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004
:
( 2 ) 2 ng/ml
TGF-beta1 could significantly
inhibit the production of cyclin A,
cyclin D1, CDK2 and CDK4, the protein levels were significantly lower than control group
Gonzalez et al., J Reprod Dev 2010
(Hyperplasia...) :
The in vitro effect of
TGF-beta1 ( 1 ng/ml ) plus progesterone ( 10 ( -6 ) M ) on purified Leydig cells from 3 week-old mice
increased the immunocytochemically detected
PCNA and stimulated the phosphorylation of Smad 1/5
Yu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
:
The
TGF-beta1 ( 5 ng/ml )
induced arrest of cells in G1 phase ( p < 0.05 ) compared with As2O3 alone and As2O3 combined with TGF-ß1, while there was no difference with control. P27 ( Kip1 ) expression was up regulated ( p < 0.05 ),
cyclin E and BCL-2 expression was down-regulated ( p < 0.05 ) in TGFß1 treated group. BCl-2 expression was down regulated, endogenesis TGFß1 expression was up regulated ( p < 0.05 ), and the level of P27 ( kip1 ) and cyclin E were not changed in As2O3 treated group ( p > 0.05 )
Stieger et al., Diabetes Metab Res Rev 2011
(Diabetes Mellitus, Type 1...) :
Common pathway components induced by high glucose and advanced glycation end-products are reactive oxygen species,
cyclin dependent kinases ( p27 ( Kip1 ) ) and
transforming growth factor-beta
Barlat et al., Oncogene 1995
:
TGF-beta 1 and cAMP
attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways
Oberhammer et al., Carcinogenesis 1995
:
As demonstrated by immunohistochemical detection of PCNA,
TGF-beta 1 prevented induction of
PCNA by epidermal growth factor (EGF)
Ko et al., Oncogene 1995
:
Cyclin D3 levels were not
affected by
TGF-beta 1 during G1 traverse
Rao et al., J Biol Chem 1995
:
Positive and negative
regulation of D-type
cyclin expression in skeletal myoblasts by basic fibroblast growth factor and
transforming growth factor beta
Schoecklmann et al., Kidney Int 1997
:
Moreover,
TGF-beta1 significantly
reduced cyclin E-associated histone H1 kinase activity in the presence of PDGF
Yoshizumi et al., J Biol Chem 1997
:
The
TGF-beta1 induced down-regulation of
cyclin A promoter activity appeared to be mediated via the activating transcription factor (ATF) site, because mutation of this site abolished down-regulation ...
TGF-beta1 induced down-regulation of
cyclin A promoter activity was reversed by okadaic acid ( a phosphatase inhibitor ) and by cotransfection with plasmids expressing the cAMP dependent protein kinase catalytic subunit or the simian virus small tumor antigen ( Sm-t, an inhibitor of PP2A )
Quesnel et al., Blood 1998
(Myelodysplastic Syndromes) :
p15(INK4b) gene is an inhibitor of
cyclin dependent kinase (CDK) 4 and CDK6 whose expression is
induced by
transforming growth factor ( TGF ) beta