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IL2 — PTPRC

Text-mined interactions from Literome

Blank et al., J Immunol 2001 : Using RT-PCR, we found that CD45R0 signaling inhibited IL-2 mRNA production without major influence on IL-13, IL-5, or IFN-gamma mRNA levels
Moro et al., Virus Genes 2001 : The high CD45RO expression in IL-2 dependent cell lines was not due to IL-2 , since IL-2 had little effect on the expression of CD45RO in T-cell lines
Koretzky et al., Proc Natl Acad Sci U S A 1991 : Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2 mediated activation of a protein tyrosine kinase and interleukin 2 production
Valentine et al., Eur J Immunol 1991 : Interleukin 2 stimulates serine phosphorylation of CD45 in CTLL-2.4 cells ... The differences in the phosphorylation patterns induced by IL2 and PMA further suggest that more than one kinase can use CD45 as substrate and that IL2 activates a protein serine/threonine kinase different from protein kinase C
Brod et al., J Exp Med 1989 : CD45RA expression could be further regulated by ionomycin or the cytokines IL-1 and IL-6, but not IL-2 , IL-4, or IFN-gamma
Bajpai et al., J Biol Chem 1994 : Role and regulation of CD45 and calyculin A-inhibited phosphatase in response to interleukin-2
Roth et al., J Exp Med 1994 : Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes ... Expression of CD45RO was observed only in response to IL-2 and was not observed during long-term culture in IL-4, IL-6, or IL-7
Estoppey et al., Eur J Immunol 1996 : We here demonstrate that engagement of CD45 by monoclonal antibodies ( mAb ) on activated T cells induces tumor necrosis factor (TNF)-alpha as well as TNF-beta, interleukin (IL)-2 and IL-3 gene expression
Crockard et al., J Neurol 1996 (Multiple Sclerosis) : IVMP therapy causes selective, but transient, inhibition of CD4CD45RA lymphocyte proliferative responses and enhancement of PHA induced IL-2 and gamma-interferon production by both CD4CD45RA and CD4CD45RO cells
Kashio et al., J Biol Chem 1998 : Specifically, replacement of CD45 D2 with that of the LAR PTPase to form a CD45/LAR:D2 chimera, abrogates CD45 dependent IL-2 production