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CPT1A — PPARA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ammerschlaeger et al., Toxicological sciences : an official journal of the Society of Toxicology 2004
:
Remarkably, no distinct peroxisome proliferation related responses were observed in human hepatocytes when rat PPARalpha was transfected, although human hepatocytes were responsive to
PPARalpha mediated induction of
carnitine palmitoyl transferase-1A and 3-hydroxy-3-methylglutaryl-CoA synthase
Le May et al., J Nutr 2005
(Carcinoma, Hepatocellular...) :
The aim of this study was to determine whether LCFA induced
L-CPT I gene expression was
mediated by
PPARalpha
Song et al., Mol Cell Endocrinol 2010
:
In the liver,
CPT-1A and PDK4 gene expression are
induced by starvation, high fat diets and
PPARalpha ligands ... Overall, our studies indicated that
PPARalpha and PGC-1alpha
stimulate transcription of the
CPT-1A gene through different regions of the CPT-1A gene
Brandt et al., J Biol Chem 1998
:
Moreover, a
PPARalpha activator did not
induce cardiac expression of the
M-CPT I gene in the PPARalpha null mice