Khan et al., Endocrinology 2002
:
IGF-I- and FSH dependent AKT phosphorylation was inhibited by LY29400 ( 10 microM ), a PI3K inhibitor , and by IGF binding protein 3 , but not by a PKA inhibitor ( H89 )
Meroni et al., J Endocrinol 2004
(MAP Kinase Signaling System) :
At the same time, it was proposed that in 8-day-old Sertoli cells the effects of FSH on phosphorylated PKB ( P-PKB ) levels can be explained by a combination of increased secretion of endogenous IGF-I, decreased IGF binding protein-3 (IGFBP-3) production, and a synergistic action of FSH on IGF-I dependent PI3K activation