Juliano et al., Nat Cell Biol 2009
(Neoplasm Invasiveness) :
SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of beta1-integrins and loss of invasive potential
Ishikawa et al., J Biol Chem 2010
:
Furthermore, overexpression of SCAI blocked activin induced SRF transcriptional responses and dendritic complexity