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PSMD4 — RPN1
Pathways - manually collected, often from reviews:
-
BioCarta proteasome complex:
26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7)
→
None
(degradation, activates)
-
BioCarta proteasome complex:
26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7)
(degradation, activates)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
PA700 lid complex (PSMD3-PSMD12-PSMD11-PSMD14)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
PA700 base complex (RPN1-RPN2-PSMD4)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 lid complex (PSMD3-PSMD12-PSMD11-PSMD14)
→
PA700 base complex (RPN1-RPN2-PSMD4)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
(modification, collaborate)
-
BioCarta proteasome complex:
26S Proteasome complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7)
→
20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
(modification, collaborate)
-
BioCarta proteasome complex:
PA700 Activator complex (PSMD3-RPN2-PSMD4-PSMD12-PSMD11-PSMD14-RPN1)
→
Hybrid Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMD3-PSMD12-PSMD11-PSMA2-PSMD14-RPN1-RPN2-PSMD4-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
(modification, collaborate)
-
BioCarta proteasome complex:
20S Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
→
Hybrid Proteasome complex (PSMA1-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-PSMD3-PSMD12-PSMD11-PSMA2-PSMD14-RPN1-RPN2-PSMD4-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7-PSMB1-PSMB2)
(modification, collaborate)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tonoki et al., Mol Cell Biol 2009
(Nerve Degeneration) :
Rpn11 overexpression
suppressed the age related reduction of the
26S proteasome activity, resulting in the extension of flies ' life spans with suppression of the age dependent accumulation of ubiquitinated proteins
Book et al., Plant Cell 2009
:
Collectively, the data point to a specific
role for
RPN5 in the plant
26S proteasome and suggest that its two paralogous genes in Arabidopsis have both redundant and unique roles in development
Kuranaga et al., RinshÅ shinkeigaku = Clinical neurology 2009
(Neurodegenerative Diseases) :
Rpn11 overexpression
suppressed the age related reduction of the
26S proteasome activity, resulting in the extension of flies ' life spans with suppression of the age dependent accumulation of ubiquitinated proteins
Lin et al., Plant Signal Behav 2012
:
Based on the reduced abundance of RP2-CP in rpn10-2 and a role of RPN10 in lid-base association, a structural
role of
RPN10 in
26S proteasome stability is likely to be more relevant in vivo