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AHSA1 — IL6

Text-mined interactions from Literome

Zauberman et al., Oncogene 1999 (Carcinoma, Hepatocellular...) : We analysed the involvement of MAPK homologues in IL-6 transduction pathways and found that interleukin-6 triggered activation of p38 stress activated protein kinase ( p38 ) but not of jun kinase
Bode et al., Biol Chem 2001 (Carcinoma, Hepatocellular) : In this study we show that activation of p38MAPK by IL-6 acts as an inhibitory signal on IL-6 mediated activation of STAT and the alpha2-macroglobulin promoter
Webb et al., J Dent Res 2002 (Osteosarcoma) : In conclusion, although p38 MAPK activation by TNF-alpha stimulates IL-6 secretion by MG-63 cells, it has opposing effects on c/EBPbeta and NFkappaB activity
Choi et al., J Neurooncol 2002 (Astrocytoma...) : Herein, we demonstrate that : ( 1 ) Among these cytokines, only IL-6 was induced upon Fas ligation in a dose- and time dependent manner ; ( 2 ) A selective p38 MAP kinase inhibitor, SB202190, and a MEK inhibitor, U0126, suppressed induction of IL-6 mRNA and protein expression by Fas ligation ; and ( 3 ) Glioblastoma multiforme samples ( n = 11 ) contain significantly higher levels of IL-6 compared to those of control brains ( n = 5 ), which correlate with increased levels of Fas
Guo et al., J Biol Chem 2003 (Inflammation) : Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6 , IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580
Frost et al., Am J Physiol Endocrinol Metab 2004 : SP-600125 ( a JNK inhibitor ) and SB-202190 ( a p38 MAP kinase inhibitor ) completely blocked epinephrine induced IL-6 synthesis
Boudreau et al., J Leukoc Biol 2004 (MAP Kinase Signaling System) : Selective p38 mitogen activated protein kinase ( p38 MAPK ) inhibition reduces OA and IgE mediated IL-6 production
Spangelo et al., Neuroimmunomodulation 2004 (Glioma...) : The pyridinylimidazole inhibitor of p38 , SB-203580, completely blocked stimulation of IL-6 release by IL-1 beta or LPC ; conversely, the anthrapyrazolone JNK inhibitor, SP-600125, was ineffective in modifying stimulated IL-6 release
Zhu et al., J Biol Chem 2005 (Inflammation) : Furthermore, p38 is critical for the production of IL-6 and IL-12 but is only marginally required for the production of TNF-alpha and nitric oxide
Thirunavukkarasu et al., Hepatology 2006 (Disease Models, Animal...) : Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin induced H ( 2 ) O ( 2 ), NO, TNF-alpha, and IL-6 synthesis
Zhao et al., J Biol Chem 2008 (MAP Kinase Signaling System) : IL-6 mRNA stability is promoted by p38alpha via 3'-UTR
Wang et al., FASEB J 2009 (MAP Kinase Signaling System) : In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord
Turner et al., Am J Physiol Heart Circ Physiol 2009 (MAP Kinase Signaling System...) : IL-1alpha induced IL-6 mRNA expression was reduced by p38 MAPK inhibition, but increased by ERK and JNK pathway inhibitors
Gaundar et al., Cell cycle (Georgetown, Tex.) 2009 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : We have demonstrated that inhibition of p38 ( MAPK ) in bone marrow stromal cells reduced the production of IL-6 , VEGF, PDGF and CXCL12
Lee et al., Eur J Pain 2010 : The increases in CX3CR1 expression, p38 MAPK activation and pain behavior after CCI were suppressed by blocking IL-6 action with a neutralizing antibody, while they were enhanced by supplying exogenous recombinant rat IL-6 ( rrIL-6 )
Hao et al., Am J Physiol Heart Circ Physiol 2010 : Finally, small interfering RNA depletion experiments revealed that p38alpha is specifically responsible for the LPA induced IL-6 secretion
Nomi et al., Invest Ophthalmol Vis Sci 2010 : The zymosan induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38 , JNK, and NF-kappaB signaling
Xie et al., J Nutr Biochem 2012 (MAP Kinase Signaling System) : This compound effectively inhibited the expression of proinflammatory cytokines TNF-a and IL-6 in low micromole levels by inhibiting NF-?B activation and p38 and JNK phosphorylation
Quétier et al., J Hepatol 2013 : Finally, the direct role of p38 in IL-6 secretion after PH was demonstrated using SB203580, a pharmacological inhibitor