Gene interactions and pathways from curated databases and text-mining

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PTK6 — SHC1

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion: BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 → SHC1/SHC3 (activation)

Text-mined interactions from Literome

Nagai et al., J Biol Chem 1995 : However, it is not clear which PTK is involved in the phosphorylation of Shc , resulting in coupling to the Ras pathway
van der Geer et al., Curr Biol 1996 : These results have suggested that Shc is a prominent effector of protein-tyrosine kinase signalling