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IFI27 — MYC

Text-mined interactions from Literome

Rocha et al., Microsc Res Tech 2003 : Second, ACTH-R triggers cAMP/PKA mediated antimitogenic mechanisms comprised of Akt/PKB dephosphorylation/deactivation, c-Myc protein degradation, and p27 ( Kip1 ) protein induction
Chandramohan et al., J Immunol 2004 : To test the effects of ectopic c-Myc on endogenous p27 levels, WEHI 231 cells stably expressing c-Myc or empty vector DNA were prepared
Bill et al., Mol Cell Biol 2004 : Adhesion of epithelial cells to the ECM failed to efficiently induce degradation of p27 , to induce cdk2 activity, or to induce Myc and cyclin A synthesis ; subsequently, cells did not progress into S phase
Nilsson et al., Cancer Cell 2005 (Lymphoma) : Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc induced suppression of the Cdk inhibitors p21(Cip1) and p27 ( Kip1 ), thereby impairing Myc 's proliferative, but not apoptotic, response
Keller et al., EMBO J 2007 (Burkitt Lymphoma...) : Therefore, Myc suppresses p27 ( Kip1 ) expression, accelerates cell proliferation and promotes tumorigenesis at least in part through its ability to selectively induce Cks1
Chandramohan et al., J Cell Biochem 2008 (Neoplasms) : As ectopic c-Myc expression in these cells prevented anti-IgM induction of p27 and cell death, we hypothesized that c-Myc represses FOXO3a mediated transcription ... The inhibition of FOXO3a mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype
Ma et al., Mol Cell Biol 2010 : Moreover, downregulation of c-Myc by Ikaros and Aiolos is necessary for the induction of p27 and downregulation of cyclin D3
Pérez-Roger et al., Oncogene 1997 : Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27 ( Kip1 ) binding to newly formed complexes