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RHOA — SMC2

Text-mined interactions from Literome

Mack et al., J Biol Chem 2001 : Coexpression of constitutively active RhoA in rat aortic SMC cultures significantly increased the activity of the SMC-specific promoters, SM22 and SM alpha-actin, whereas coexpression of C3 transferase abolished the activity of these promoters ... Taken together, the results of these studies indicate that in SMC, RhoA dependent regulation of the actin cytoskeleton selectively regulates SMC differentiation marker gene expression by modulating SRF dependent transcription
Wamhoff et al., Circ Res 2004 : We tested the hypothesis that Ca2+ influx through VGCCs regulates SMC differentiation marker expression and that these effects are dependent on RhoA/ROK signaling
Staus et al., Arterioscler Thromb Vasc Biol 2007 : Activation of mDia1/2 signaling by RhoA strongly stimulated SMC-specific promoter activity in multiple cell-types including primary aortic SMCs, and stimulated endogenous SM alpha-actin expression in 10T1/2 cells
Patel et al., Am J Physiol Gastrointest Liver Physiol 2007 : To examine the molecular bases for the myogenic tone in the IAS, the present studies focused on the role of RhoA/ROCK in the SMC isolated from the IAS vs. the adjoining phasic tissues of the rectal smooth muscle ( RSM ) and anococcygeus smooth muscle ( ASM ) of rat