Morisaki et al., Atherosclerosis 1988
:
Exogenously added PGI2 or its stable analogue, CS-570, was observed to inhibit DNA synthesis of medial SMC enhanced by indomethacin but not that of intimal SMC ... These results indicate that medial SMC are negatively controlled by endogenous PGI2 and that intimal SMC have no such negative control system for cell proliferation
Larrue et al., Atherosclerosis 1984
:
The present results suggest a potential role for PGI2 in SMC differentiation and proliferation