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ATF4 — CASP12

Text-mined interactions from Literome

Lin et al., Anticancer Res 2007 (Nasopharyngeal Neoplasms) : Moreover, for the first time in NPC cells it was demonstrated that the pathway involved in rhein induced apoptosis is caspase dependent, presumably through the endoplasmic reticulum ( ER ) stress pathway, as shown by an increase in the levels of glucose regulated protein 78 (GRP 78), PKR-like ER kinase (PERK), activating transcription factor 6 ( A TF6 ) and CCAA TIenhancer binding protein homologous protein ( CHOP ) as well as the activation of caspase-3 , -8, -9 and -12
Zhang et al., Neurosci Lett 2010 : These results indicate that both the PERK/eIF2 alpha/ATF4 ISR and activation of caspase-12 may be involved in apoptosis of spinal cord astrocytes induced by OGSD/restoration
Fan et al., Brain Res 2013 : Edaravone protects against glutamate induced PERK/EIF2a/ATF4 integrated stress response and activation of caspase-12