Herman et al., Clin Exp Rheumatol 2008
(Acute Disease...) :
Our results show that MTX induces IL-10 secretion ( a TH2 cytokine ) and significantly reduces TH1 profile in Peripheral Mononuclear Cells ( PMNC ) derived from active RA patients ( n=28 ) ... A significant correlation was found between MTX IL-10 induction and NO inhibition in active RA patients
Meyer et al., J Rheumatol 1993
(Arthritis, Rheumatoid) :
MTX had no effect on interleukin 1 stimulated production of prostaglandin E, hyaluronic acid and collagenase
Durez et al., Eur Cytokine Netw 1998
:
We investigated the effects of methotrexate (MTX) on the production of tumor necrosis factor (TNF), nitric oxide ( NO ) and interleukin-10 (IL-10) in vivo