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PRKAB2 — SREBF1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhou et al., J Clin Invest 2001
(Diabetes Mellitus, Type 2) :
Activation of
AMPK by metformin or an adenosine analogue
suppresses expression of
SREBP-1 , a key lipogenic transcription factor
You et al., Gastroenterology 2004
(Fatty Liver, Alcoholic...) :
Moreover, activation of
AMPK by metformin or AICAR largely
blocked the ability of ethanol to increase levels of mature
SREBP-1 protein
Kohjima et al., Int J Mol Med 2008
(Fatty Liver) :
It is known that
SREBP-1c is negatively
regulated by
AMP activated protein kinase (AMPK) but expression levels of AMPK in NAFLD were almost equal to those of the controls
Park et al., Hepatology 2008
(Carcinoma, Hepatocellular...) :
ALA increased AMPK phosphorylation in the liver and in cultured liver cells, and dominant negative
AMPK partially
prevented ALA induced suppression of insulin stimulated
SREBP-1c expression
Yang et al., J Cell Biochem 2009
:
It has long been documented that
AMPK activation
suppresses hepatic SREBP-1 mRNA and nuclear
SREBP-1 protein ... We found that AMPK is robustly activated in rat hepatoma McA-RH7777 cells treated with two widely used AMPK activators, AICAR and metformin, and
AMPK activation sharply
suppresses SREBP-1c mRNA and nuclear
SREBP-1c protein, but not SREBP-1a mRNA derived from the same gene ...
AMPK does not
enhance SREBP-1c mRNA degradation in the presence of the general transcription inhibitor actinomycin D ; instead it inhibits SREBP-1c promoter activity in a luciferase reporter assay ...
AMPK mediated inhibition of
SREBP-1c promoter activity can also be abrogated by the AMPK inhibitor Compound C ... Furthermore
AMPK activation significantly
attenuates the synthetic liver X receptor ( LXR ) ligand T0901317 induced
SREBP-1c promoter activity ... We conclude that
AMPK suppresses hepatic
SREBP-1c mRNA expression by inhibiting LXR dependent SREBP-1c transcription via inhibition of endogenous LXR ligand production and by inhibiting SREBP-1c processing in McA-RH7777 cells
Kim et al., J Agric Food Chem 2009
(Carcinoma, Hepatocellular...) :
Taken together,
AMPK mediates CK induced suppression and activation of
SREBP1c and PPAR-alpha, respectively, and these effects seem to be one of antidiabetic and/or antihyperlipidemic mechanisms of CK in insulin-resistant HepG2 human hepatoma cells
Li et al., Cell Metab 2011
(Atherosclerosis...) :
AMPK stimulates Ser372 phosphorylation, suppresses SREBP-1c cleavage and nuclear translocation, and
represses SREBP-1c target gene expression in hepatocytes exposed to high glucose, leading to reduced lipogenesis and lipid accumulation
Jung et al., J Lipid Res 2011
(Fatty Liver) :
OA-induced
SREBP-1 transcriptional activity was
suppressed by cotreatment with aminoimidazole carboxamide ribonucleotide ( AICAR ) or metformin, or by overexpression of constitutively active
AMPK ( CA-AMPK ) in the human hepatoma cell line
Hu et al., Hepatology 2012
(Fatty Liver, Alcoholic) :
CONCLUSION : In conclusion, ethanol induced up-regulation of lipin-1 gene expression is mediated through inhibition of
AMPK and
activation of
SREBP-1
Pil Hwang et al., Mol Nutr Food Res 2013
:
These results indicate that CDCQ prevented lipid accumulation by blocking the expression of
SREBP-1c and FAS through LKB1/SIRT1 and
AMPK activation in HepG2 cells, suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation
Quan et al., Biochem Pharmacol 2013
(Fatty Liver) :
We found that BA activates
AMPK via phosphorylation,
suppresses SREBP1 mRNA expression, nuclear translocation and repressed SREBP1 target gene expression in HepG2 cells and primary hepatocytes, leading to reduced lipogenesis and lipid accumulation
Hwang et al., Food Chem 2013
:
Moreover, the use of a pharmacological AMPK inhibitor revealed that
AMPK is
essential for the suppression of
SREBP-1c expression in CKS treated cells
Jin et al., Toxicol Appl Pharmacol 2013
:
We found that the ability of resveratrol to repress T0901317 induced
SREBP-1c expression was not
dependent on
AMPK and Sirt1