◀ Back to TP53
ICAM1 — TP53
Text-mined interactions from Literome
Gorgoulis et al., EMBO J 2003
:
p53 activates
ICAM-1 ( CD54 ) expression in an NF-kappaB independent manner ... These results support an NF-kappaB independent
role for
p53 in
ICAM-1 regulation that may link p53 to ICAM-1 function in various physiological and pathological settings
Gorgoulis et al., Lab Invest 2005
(Arteriosclerosis) :
p53 dependent
ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions ... We have recently reported that the transcriptional activator
p53 can
trigger ICAM-1 expression in an nuclear factor-kappa B (NF-kappaB) independent manner ( Gorgoulis et al, EMBO J. 2003 ; 22 : 1567-1578 ) ... As p53 exhibits an increased transcriptional activity in senescent cells, we investigated whether
p53 activation is
responsible for the senescence associated
ICAM-1 overexpression ... Here, we present evidence from both cell systems to support a
p53 mediated
ICAM-1 overexpression in senescent cells that is independent of NF-kappaB
Thanopoulou et al., Tumour Biol 2012
(Carcinoma, Non-Small-Cell Lung...) :
Moreover, the expression of
ICAM-1 is transcriptionally
regulated by
p53 , and this SNP has been shown to be related with apoptosis