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SETD2 — STAT3
Text-mined interactions from Literome
Xu et al., Oncogene 2005
(Neoplasms) :
Targeting
Stat3 blocks both
HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways ... Targeting
Stat3 with a small-molecule inhibitor
blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo
Niu et al., Zhongguo Dang Dai Er Ke Za Zhi 2007
(Kidney Neoplasms...) :
Stat3 may
regulate the expression of
HIF-1 and VEGF, so it could be an effective target for inhibiting VEGF expression and angiogenesis of Wilms ' tumor
Wheeler et al., Oncogene 2010
(Carcinoma, Squamous Cell...) :
These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased
STAT3 activation and
induction of
HIF1-a , which contribute to cetuximab resistance in EGFRvIII expressing HNSCC tumors
Boreddy et al., PloS one 2011
(Neoplasm Invasiveness...) :
STAT-3 over-expression or IL-6 treatment significantly
induced HIF-1a and VEGF expression ; however, BITC substantially suppressed
STAT-3 as well as STAT-3 induced HIF-1a and VEGF expression
Adachi et al., Oral Oncol 2012
(Carcinoma, Squamous Cell...) :
STAT3 mediated
HIF-1a expression was also reduced in response to Stattic treatment
Albasanz-Puig et al., Biochem Biophys Res Commun 2012
:
STAT-1 suppresses HIF-1a expression, whereas
STAT-3 positively
regulates HIF-1a expression ... These results provide evidence that activated STAT-1 and
STAT-3 regulate VEGF expression indirectly, by modulating
HIF-1a activity
Nechemia-Arbely et al., Clin Exp Pharmacol Physiol 2013
:
These in vivo studies suggest that, in response to renal hypoxic-stress, upregulation of
HIF-1 and
activation of
STAT3 may be both reciprocal and cell type dependent
Pawlus et al., PloS one 2013
:
Using siRNA or inhibitor, we previously reported that
STAT3 or USF2 is specifically
required for activation of endogenous
HIF1 or HIF2 target genes