◀ Back to TNF

TNF — TRPC1

Text-mined interactions from Literome

Paria et al., J Biol Chem 2003 : Tumor necrosis factor-alpha induces nuclear factor-kappaB dependent TRPC1 expression in endothelial cells ... Treatment with NEMO binding domain peptide, which prevents NF-kappaB activation by selectively inhibiting IKKgamma interaction with IKK complex, also blocked the TNF-alpha induced TRPC1 expression ... Thus, TNF-alpha induces TRPC1 expression through an NF-kappaB dependent pathway in endothelial cells, which can trigger augmented Ca2+ entry following Ca2+ store depletion
Paria et al., Am J Physiol Lung Cell Mol Physiol 2004 : Tumor necrosis factor-alpha induced TRPC1 expression amplifies store operated Ca2+ influx and endothelial permeability
Tiruppathi et al., Microcirculation 2006 (Calcium Signaling...) : Further, evidence suggests that the inflammatory cytokine tumor necrosis factor-alpha can induce the expression of TRPC1 in human vascular endothelial cells signaling via the nuclear factor-kappaB pathway
Hai et al., Am J Physiol Gastrointest Liver Physiol 2011 (Calcium Signaling) : Inhibitors of NF-?B ( curcumin, SN-50 ) attenuated TNF-a induced enhancement of TRPC1 expression, store dependent Ca ( 2+ ) influx, and COX-2 dependent PGE ( 2 ) production