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FRS2 — NTRK1

Pathways - manually collected, often from reviews:

• KEGG Neurotrophin signaling pathway: NTRK1 → FRS2 (protein-protein, activation)
• NCI Pathway Database SHP2 signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database SHP2 signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family (FRS3/FRS2) (modification, activates) Meakin et al., J Biol Chem 1999, Ong et al., Mol Cell Biol 2000, Dixon et al., Biochim Biophys Acta 2006, Guiton et al., J Biol Chem 1995, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Kao et al., J Biol Chem 2001
  Evidence: physical interaction
• Reactome Reaction: NTRK1 → FRS2 (reaction) Ong et al., Mol Cell Biol 2000
• Reactome Reaction: FRS2 → NTRK1 (reaction) Kouhara et al., Cell 1997
• Reactome Reaction: NTRK1 → FRS2 (indirect_complex) Ong et al., Mol Cell Biol 2000, Knudsen et al., J Biol Chem 1994*, Kouhara et al., Cell 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: NTRK1 — FRS2 Ong et al., Mol Cell Biol 2000
• IRef Bind_translation Interaction: NTRK1 — FRS2 (affinity chromatography technology) Ong et al., Mol Cell Biol 2000
• IRef Bind_translation Interaction: NTRK1 — FRS2 (coimmunoprecipitation) Ong et al., Mol Cell Biol 2000
• IRef Biogrid Interaction: FRS2 — NTRK1 (direct interaction, pull down) Meakin et al., J Biol Chem 1999
• IRef Biogrid Interaction: FRS2 — NTRK1 (direct interaction, two hybrid) Meakin et al., J Biol Chem 1999
• IRef Hprd Interaction: FRS2 — NTRK1 (in vitro) Meakin et al., J Biol Chem 1999
• IRef Ophid Interaction: NTRK1 — FRS2 (aggregation, confirmational text mining) Meakin et al., J Biol Chem 1999
• IRef Ophid Interaction: NTRK1 — FRS2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

MacDonald et al., J Mol Neurosci 1999 : The interaction with trkA is not affected by mutations at either Tyr499 or Tyr794, the two major phosphotyrosine residues essential to the activation and receptor binding of Shc, FRS-2/SNT , and phospholipase Cgamma-1, and it is highly specific in vitro for trkA, with little or no binding observed with trkB and/or trkC ... The interaction with trkA is not affected by mutations at either Tyr499 or Tyr794, the two major phosphotyrosine residues essential to the activation and receptor binding of Shc, FRS-2/SNT , and phospholipase Cgamma-1, and it is highly specific in vitro for trkA, with little or no binding observed with trkB and/or trkC
Zeng et al., J Neurochem 2002 : Collectively, these data suggest a model in which NGF stimulated TrkA dependent activation of FRS2 supports neurite outgrowth through a mechanism that likely involves the induction of p21 ( Waf1/Cip1 ) expression and the arrest of cells at G(1) /S